Cardiac tumors other diagnostic studies

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Template:Dj

Overview

Cardiac Tumors Biopsy Findings

Biopsy findings associated with cardiac tumors include the following:
Cardiac Tumors Biopsy Findings
Tumor Biopsy Findings
Myxoma Hemorrhages, spindle or stellate cells, pseudovascular structure, myxoid matrix.
  • There may be dystrophic calcification present.
Cardiac Lipoma Histopathologically, a cardiac lipoma is constituted of
  • mature fat cells, fibrous connective tissue, and
  • vacuolated brown fat.
Cardiac Fibroma Histologically, fibromas are predominantly made of
  • fibroblasts or collagen, with the characteristic "spindle cells."
  • Calcification of fibromas is especially prevalent among elderly people
Fibroelastoma Histopathologically, a cardiac lipoma is constituted of
  • endocardium-coated fronds contain an avascular collagenous core.
Rhabdomyoma Cardiac rhabdomyomas are characterized by
  • classic spider cells, polygonal myocytes with conspicuous sarcoplasmic clearing.
  • Rhabdomyomas are formed of enlarged, vacuolated cardiomyocytes.
Fibroelastomas
  • It consists of endocardium-coated fronds surrounding an avascular collagenous core.[1]
Mesothelioma Histopathology Mesothelioma cells can exhibit three different configurations,
  • namely largely epithelial, mostly fibrous (spindle cell), and biphasic (mixed).
  • Carcinoembryonic antigen (CEA) and positive mesothelial markers (calretinin and cytokeratins) may effectively distinguish mesotheliomas from pericardial metastases of adenocarcinoma.[2]
Cystic Tumor of the Atrioventricular Node The tumor is found on the right side of the central fibrous body, invading and squeezing the AV node histologically.
  • The lesions are packed by a mucoid  material and are bordered by epithelium, cytokeratin, and epithelial membrane antigen positive.[3]
Hemangioma histologically characterized
  • by small capillaries (capillary hemangioma), big vessels (cavernous hemangioma, the most frequent kind), or dysplastic vessels (cirsoid aneurysm).
Hamartoma of Cardiac Myocytes Lesions are defined histologically by a
  • nodular cluster of enlarged, highly disordered cardiomyocytes.[4]

References

  1. Maleszewski JJ, Anavekar NS, Moynihan TJ, Klarich KW (2017). "Pathology, imaging, and treatment of cardiac tumours". Nat Rev Cardiol. 14 (9): 536–549. doi:10.1038/nrcardio.2017.47. PMID 28436488.
  2. Nilsson A, Rasmuson T (2009). "Primary Pericardial Mesothelioma: Report of a Patient and Literature Review". Case Rep Oncol. 2 (2): 125–132. doi:10.1159/000228894. PMC 2918860. PMID 20740175.
  3. Moorjani N, Kuo J, Wilkins D (2004). "Left atrial phaeochromocytoma". Heart. 90 (11): e64. doi:10.1136/hrt.2004.041319. PMC 1768537. PMID 15486108.
  4. ElBardissi AW, Dearani JA, Daly RC, Mullany CJ, Orszulak TA, Puga FJ; et al. (2008). "Analysis of benign ventricular tumors: long-term outcome after resection". J Thorac Cardiovasc Surg. 135 (5): 1061–8. doi:10.1016/j.jtcvs.2007.10.048. PMID 18455585.

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