Brodie abscess pathophysiology
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Brodie abscess Microchapters |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Abdulkerim Yassin, M.B.B.S[2]
Overview
Local trauma and bacteremia lead to increased susceptibility to bacterial seeding of the metaphysis. History of trauma is reported in 30% of patients.
Pathophysiology
- Local trauma and bacteremia lead to increased susceptibility to bacterial seeding of the metaphysis. History of trauma is reported in 30% of patients. Brodie abscess arises where the bacteria and the host defenses are equally balanced. To reduce the systemic response, the abscess is walled-off. An osseous infection can be caused by hematogenous spread of pathogens to bone or by direct inoculations by bacteria. The organisms reach the bone from a disrupted site else where in the body such as a skin pustule, furuncles, impetigo, infected blisters and burns, or secondary to an infection of another organ system (urogenital infections, enteritis, cholangitis or endocarditis. [1]
References
- ↑ Schmoldt A, Benthe HF, Haberland G (1975). "Digitoxin metabolism by rat liver microsomes". Biochem Pharmacol. 24 (17): 1639–41. PMID DOI:10.5334/jbr-btr.145 Check
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