Macroglobulinemia
| Macroglobulinemia | |
| ICD-9 | 273.3 |
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| MeSH | D008258 |
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Evidence Based Medicine |
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Cochrane Collaboration on Macroglobulinemia |
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US National Guidelines Clearinghouse on Macroglobulinemia NICE Guidance on Macroglobulinemia
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Causes & Risk Factors for Macroglobulinemia |
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Macroglobulinemia is the presence of increased levels of macroglobulins in the circulating blood. A plasma cell dyscrasia resembling leukemia with cells of lymphocytic, plasmacytic, or intermediate morphology, which secrete an immunoglobulin M monoclonal component. There is diffuse infiltration of bone marrow and also, in many cases, of the spleen, liver, or lymph nodes. The circulating macroglobulin produces symptoms of hyperviscosity syndrome: weakness, fatigue, bleeding disorders, and visual disturbances. Peak incidence is in the sixth and seventh decades. (Dorland, 28th ed)