Chronic pancreatitis
| Chronic pancreatitis | |
| ICD-10 | K86.0-K86.1 |
|---|---|
| ICD-9 | 577.1 |
| OMIM | 167800 |
| DiseasesDB | 9559 |
| MedlinePlus | 000221 |
| eMedicine | med/1721 |
| MeSH | D050500 |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
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Overview
Chronic pancreatitis is a long-standing inflammation of the pancreas that alters its normal structure and functions. It can present as episodes of acute inflammation in a previously injured pancreas, or as chronic damage with persistent pain or malabsorption.
Causes
At least 70% of adult cases are caused by chronic alcohol use, and most patients have consumed more than 150 g/day of alcohol over six to twelve years.[1] Gallstone-associated pancreatitis is predominantly acute or relapsing-acute in nature, and some cases of chronic pancreatitis are of undetermined or idiopathic origin. A few are inherited or secondary to Sphincter of Oddi dysfunction (SOD). Other less frequent causes include chronic steroid and or anti-inflammatory use. In up to one quarter of cases, no cause can be found. Autoimmune pancreatitis is increasingly recognized and may be associated with raised IgG4 levels, other autoimmune features and bile duct involvement.
Cystic fibrosis is the most common cause of chronic pancreatitis in children. In other parts of the world, severe protein-energy malnutrition is a common cause.
References
- ↑ Nair RJ, Lawler L, Miller MR (2007). "Chronic pancreatitis". Am Fam Physician. 76 (11): 1679–88. PMID 18092710.