Pseudo-Cushing's syndrome (patient information)

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How do I know if I have pseudo-Cushing's syndrome and what are the symptoms of pseudo-Cushing's syndrome?

Signs of patients with pseudo-Cushing's syndrome are similar to Cushing's syndrome. They include the following characteristics.

• Truncal obesity, plethoric moon face, buffalo hump
• Supraclavicular fat pads
• Hirsutism and menstrual irregularities in women
• Thin skin with easy bruising and wide, purplish striae
• Hypertension
• Increased appetite, weight gain
• Depression, or mood swings, anxiety
• Fatigue
• Trouble sleeping

Who is at risk for pseudo-Cushing's syndrome?

• Alcoholism or alcohol withdrawal
• Severe stresses
• Psychiatric conditions such as depression, panic disorders and psychotic conditions.

How to know you have pseudo-Cushing's syndrome?

• Salivary cortisol level: Measurement of ate-night salivary cortisol concentrations can be used as a screening test in suspected pseudo-Cushing's syndrome.
• The 24-hour urinary free cortisol (UFC): In this test, a patient’s urine is collected several times over a 24-hour period and tested for cortisol. Patients with pseudo-Cushing's syndrome may show moderately increased in the 24-hour urinary free cortisol (UFC) level.
• Blood level of cortisol: Patients with pseudo-Cushing's syndrome may show elevated levels of serum cortisol in the morning and evening and the morning level is not suppressed to less than 5 µg/dL by 1 mg dexamethasone administered at midnight. A midnight cortisol level of less than 7.5 µg/dL is an important difference between pseudo-Cushing and true Cushing's syndrome.
• Liver function: Elevation of serum transaminase levels suggest alcohol-induced hepatitis.
• Blood alcohol level: Because many patients of pseudo-Cushing's syndrome are caused by alcohol abuse, blood alcohol level may be helpful.

When to seek urgent medical care?

Call your health care provider if symptoms of pseudo-Cushing's syndrome develop. If you experience either of the following symptoms, seeking urgent medical care as soon as possible:

• Severe hypertension

Treatment options

Treatments of pseudo-Cushing's syndrome depend on the cause. There is nspecific medications for this disorder.

• Anticipate and prevent alcohol withdrawal syndrome.
• Treat psychiatric conditions, relieve stresses.

Diseases with similar symptoms

• Cushing's syndrome
• Depression

Where to find medical care for pseudo-Cushing's syndrome?

Directions to Hospitals Treating pseudo-Cushing's syndrome

Prevention of pseudo-Cushing's syndrome

• Avoidance of alcohol abuse.
• Avoidance too much pressure. If needed, go to see your psychologist.

What to expect (Outook/Prognosis)?

Prognosis of pseudo-Cushing's syndrome varies, depending on the cause and the person. With abstinence from alcohol, all biochemical abnormalities return to reference ranges. But patients with chronic alcoholism often relapse.

Copyleft Sources

http://emedicine.medscape.com/article/124718-overview

http://www.empowher.com/news/herarticle/2009/03/24/what-pseudo-cushings

http://www.pituitary.org/library/library_detail.aspx?page_id=1290