Lymphoma

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List of terms related to Lymphoma

	Lymphoma;
	Lymph node: Malignant Lymphoma Large Cell Type: Gross natural color excellent view of cut mesentery showing massively enlarged mesenteric nodes with focal hemorrhages case diagnosed several years ago as reticulum cell sarcoma excellent demonstration of nodes with lymphoma. ; Image courtesy of Professor Peter Anderson DVM PhD and published with permission © PEIR, University of Alabama at Birmingham, Department of Pathology
ICD-10	C81-C96
ICD-O:	9590-9999
MeSH	D008223

For patient information click here

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Associate Editor-in-Chief: Ross Bonander

Please Take Over This Page and Apply to be Editor-In-Chief for this topic: There can be one or more than one Editor-In-Chief. You may also apply to be an Associate Editor-In-Chief of one of the subtopics below. Please mail us [2] to indicate your interest in serving either as an Editor-In-Chief of the entire topic or as an Associate Editor-In-Chief for a subtopic. Please be sure to attach your CV and or biographical sketch.

Overview

Lymphoma is a type of cancer that originates in lymphocytes (a type of white blood cell in the vertebrate immune system). There are many types of lymphoma. Lymphomas are part of the broad group of diseases called hematological neoplasms.

In the 19th and 20th centuries the affliction was called Hodgkin's Disease, as it was discovered by Thomas Hodgkin in 1832. Colloquially, lymphoma is broadly categorized as Hodgkin's lymphoma and non-Hodgkin lymphoma (all other types of lymphoma). Scientific classification of the types of lymphoma is more detailed.

Although older classifications referred to histiocytic lymphomas, these are recognized in newer classifications as of B, T or NK cell lineage. Histiocytic malignancies are rare and are classified as sarcomas.^[1]

Prevalence

According to the U.S. National Institutes of Health, lymphomas account for about five percent of all cases of cancer in the United States, and Hodgkin's lymphoma in particular accounts for less than one percent of all cases of cancer in the United States.

Because the lymphatic system is part of the body's immune system, patients with a weakened immune system, such as from HIV infection or from certain drugs or medication, also have a higher incidence of lymphoma.

Classification

WHO classification

The WHO Classification is the latest classification of lymphoma, published by the World Health Organization in 2001.^[1] It was based upon the "Revised European-American Lymphoma classification" (REAL).

This classification attempts to classify lymphomas by cell type, i.e. the normal cell type that most closely resembles the tumor. They are classified in three large groups: the B cell tumors, the T cell and natural killer cell tumors, Hodgkin lymphoma, and other minor groups: (ICD-O codes are provided where available)

Mature B cell neoplasms

- Chronic lymphocytic leukemia/small lymphocytic lymphoma
- B-cell prolymphocytic leukemia
- Lymphoplasmacytic lymphoma
- Splenic marginal zone B-cell lymphoma (with or without villous lymphocytes)
- Hairy cell leukemia
- Splenic lymphoma/leukemia, unclassifiable
- Plasma cell myeloma/plasmacytoma
- Heavy chain diseases
- Extranodal marginal zone B-cell lymphoma of MALT type (MALT lymphoma)
- Nodal marginal zone B-cell lymphoma (with or without monocytoid B cells)
- Follicular lymphoma
- Primary cutaneous follicle center lymphoma
- Mantle cell lymphoma
- Diffuse large B-cell lymphoma (DLBCL)
  - Diffuse large B-cell lymphoma, not otherwise specified
  - T-cell /histiocyte rich large B-cell lymphoma
  - DLBCL associated with chronic inflammation
  - EBV positive DLBCL of the elderly
  - Lymphomatoid granulomatosis
  - Primary mediastinal (thymic) large B-cell lymphoma
  - Intravascular large B-cell lymphoma
  - Primary cutaneous DLBCL, leg type
  - ALK positive DLBCL
  - Plasmablastic lymphoma
  - Primary effusion lymphoma
  - Large B-cell lymphoma arising in HHV8-associated multicentric Castleman's disease
- Burkitt lymphoma/Burkitt cell leukemia
- B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and Burkitt lymphoma
- B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and classical Hodgkin lymphoma

B-cell proliferations of uncertain malignant potential

- Lymphomatoid granulomatosis
- Post-transplant lymphoproliferative disorder

DNA-microarray analysis of Burkitt's lymphoma and diffuse large B-cell lymphoma (DLBCL) showing differences in gene expression patterns. Colors indicate levels of expression; green indicates genes that are overexpressed in normal cells compared to lymphoma cells and red indicates genes that are overexpressed in lymphoma cells compared to normal cells.

Mature T cell and natural killer (NK) cell neoplasms

Leukemic/disseminated

T cell prolymphocytic leukemia
T cell large granular lymphocytic leukemia
Aggressive NK cell leukemia
Adult T-cell leukemia/lymphoma (ATLL)

Cutaneous

Mycosis fungoides
Sezary syndrome
Primary cutaneous CD30-positive T cell lymphoproliferative disorders
- Primary cutaneous anaplastic large cell lymphoma
- Lymphomatoid papulosis

Other extranodal

Extranodal NK/T cell lymphoma, nasal type
Enteropathy-type T cell lymphoma
Hepatosplenic T cell lymphoma
Subcutaneous pannicultis-like T cell lymphoma

Nodal

Peripheral T cell lymphoma, NOS (not otherwise specified)
Angioimmunoblastic T cell lymphoma
Primary systemic anaplastic large cell lymphoma

Neoplasms of uncertain lineage, stage of differentiation

Blastic NK cell lymphoma

Hodgkin Lymphoma

- Nodular lymphocyte-predominant Hodgkin lymphoma
- Classical Hodgkin lymphoma
  - Nodular sclerosis
  - Mixed cellularity
  - Lymphocyte-rich
  - Lymphocyte depleted or not depleted

Immunodeficiency-associated lymphoproliferative disorders

- Associated with a primary immune disorder
- Associated with the Human Immunodeficiency Virus (HIV)
- Post-transplant
- Associated with Methotrexate therapy

Working formulation

The Working Formulation, published in 1982, is primarily descriptive. It is still occasionally used, but has been superseded by the WHO classification, above.

Low grade

Malignant Lymphoma, small lymphocytic (chronic lymphocytic leukemia)
Malignant Lymphoma, follicular, predominantly small cleaved cell
Malignant Lymphoma, follicular, mixed (small cleaved and large cell)

High grade

Malignant Lymphoma, large cell, immunoblastic
Malignant Lymphoma, lymphoblastic
Malignant Lymphoma, small non-cleaved cells (Burkitt's lymphoma)

Miscellaneous

Composite
Histiocytic
Extramedullary plasmacytoma
Unclassifiable

Other classification systems

ICD-O (codes 9590-9999, details at [3])
ICD-10 (codes C81-C96, details at [4])

For diagnosis, etiology, staging, prognosis, and treatment

Please see separate links to Hodgkin's lymphoma and non-Hodgkin's lymphoma.

Genetics

Enteropathy associated T-cell lymphoma (EATL) is environmentally induced as a result of the consumption of Triticeae glutens. In gluten sensitive individuals with EATL 68% are homozygotes of the DQB1*02 subtype at the HLA-DQB1 locus (serotype DQ2).^[2] (See Coeliac Disease, HLA-DQ, HLA DR3-DQ2)

References

↑ ^1.0 ^1.1 Pathology and Genetics of Haemo (World Health Organization Classification of Tumours S.). Oxford Univ Pr. ISBN 92-832-2411-6.
↑ Al-Toma A, Verbeek WH, Hadithi M, von Blomberg BM, Mulder CJ (2007). "Survival in Refractory Coeliac Disease and Enteropathy associated T cell Lymphoma: Retrospective evaluation of single centre experience". doi:10.1136/gut.2006.114512. PMID 17470479.

External links

Research Foundations and Working Groups

Information

Societies and Support Groups

Statistics

Template:Hematology

Template:SIB bg:Лимфома ar:سرطان الغدد الليمفاوية de:Malignes Lymphom eu:Linfoma ia:Lymphoma it:Linfoma he:לימפומה lt:Limfoma nl:Maligne lymfoom no:Lymfekreft fi:Lymfooma

Template:WikiDoc Sources

[isbn92-832-2411-6-1] 1.0 ^1.1 Pathology and Genetics of Haemo (World Health Organization Classification of Tumours S.). Oxford Univ Pr. ISBN 92-832-2411-6.

[pmid17470479-2] Al-Toma A, Verbeek WH, Hadithi M, von Blomberg BM, Mulder CJ (2007). "Survival in Refractory Coeliac Disease and Enteropathy associated T cell Lymphoma: Retrospective evaluation of single centre experience". doi:10.1136/gut.2006.114512. PMID 17470479.

[1]

[2]

v t e Myeloid Hematological malignancy/leukemia histology (ICD-O 9590-9989, C81-C96, 200-208)
CFU-GM/ and other granulocytes	Template:Navbox subgroup
MEP	Template:Navbox subgroup
CFU-Mast	Mastocytoma (Mast cell leukemia, Mast cell sarcoma, Systemic mastocytosis)
Multiple/unknown	AML (Acute panmyelosis with myelofibrosis, Myeloid sarcoma) · MP (Myelofibrosis) · Acute biphenotypic leukaemia
See also hematology, lymphoid malignancy


Lymphoma
Lymph node: Malignant Lymphoma Large Cell Type: Gross natural color excellent view of cut mesentery showing massively enlarged mesenteric nodes with focal hemorrhages case diagnosed several years ago as reticulum cell sarcoma excellent demonstration of nodes with lymphoma. Image courtesy of Professor Peter Anderson DVM PhD and published with permission © PEIR, University of Alabama at Birmingham, Department of Pathology
ICD-10	C81-C96
ICD-O:	9590-9999
MeSH	D008223