Pulmonary hypertension laboratory tests
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Lab
- Biochemistry,hematology and Thyroid function tests are required in all patients with pulmonary Hypertension.(Important for diagnosis of Chronic Hemolytic anemia,myeloproliferative disorders,thyroid disorders chronic renal failure on dialysis as casues of the pulmopnary Hypertension).
- Serologic testing to detect Connective tissue diseases(Systemic Sclerosis), HIV and Hepatitis.
Systemic sclerosis is very important to exclude in pulmonary hypertension becuase this systemic disease has a very high prevalence of Pulmonary arterial hypertension.Anti-Scl-70, anti-centromere,and U3-RNP(mostly in diffuse systemic sclerosis) are typically positive.
- Liver function tests to exclude portal hypertension.
- Both ANP and BNP have been shown to correlate with the survival in Idiopathic Pulmonary Hypertension,However NT-proBNP appear to be an independant predictor of survival and correlates with RV dysfunction.
- Serum uric acid: reflects impaired oxidative metabolism of ischemic peripheral tissues..