Cardiology overview pharmacology
Cardiology Overview |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Drug Drug Interactions
- Cyclosporin co-administration is associated with a higher rate of myositis among statin users as a result of inhibition of CYP3A4. The exception is pravastatin in which this is not a problem.
Drug Food Interactions
Grapefruit
- Grapefruit juice inhibits the Cyp 3A4 enzyme which reduces the breakdown of drugs. Grapefruit juice also increases the p- glycoprotein in the intestines which increases drug absorption.
- Amiodarone
- Nifedipine
- Simvastatin