Alprazolam contraindications
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
List of contraindications
Benzodiazepine sensitivity
Narrow angle glaucoma
Ketoconazole & itraconazole
Benzodiazepine sensitivity
Alprazolam is contraindicated in patients with known sensitivity to this drug or other benzodiazepines. Return to top
Narrow angle glaucoma
Alprazolam may be used in patients with open angle glaucoma who are receiving appropriate therapy, but is contraindicated in patients with acute narrow angle glaucoma. Return to top
Ketoconazole & itraconazole
Alprazolam is contraindicated with ketoconazole and itraconazole, since these medications significantly impair the oxidative metabolism mediated by cytochrome P450 3A (CYP3A). Return to top
Adapted from the FDA Package Insert.