Myelodysplastic syndrome laboratory findings
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Abnormalities include:
- neutropenia, anemia and thrombocytopenia (low cell counts of white and red blood cells, and platelets, respectively)
- abnormal granules in cells, abnormal nuclear shape and size
- chromosomal abnormalities, including chromosomal translocations and abnormal chromosome number.
Laboratory Tests
- Full blood count and examination of blood film. The blood film morphology can provide clues about hemolytic anemia, clumping of the platelets leading to spurious thrombocytopenia, or leukemia.
- Blood tests to eliminate other common causes of cytopenias, such as lupus, hepatitis, B12, folate, or other vitamin deficiencies, renal failure or heart failure, HIV, hemolytic anemia, monoclonal gammopathy. Age-appropriate cancer screening should be considered for all anemic patients.