Primary sclerosing cholangitis
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Primary sclerosing cholangitis Microchapters |
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Differentiating Primary sclerosing cholangitis from other Diseases |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Signs and symptoms
Diagnosis
Etiology
Pathophysiology
Epidemiology
Screening
Therapy
Standard treatment includes ursodiol, a bile acid naturally produced by the liver, which has been shown to lower elevated liver enzyme numbers in people with PSC, but has not yet been proven effective at prolonging the life of the liver. Treatment also includes medication to relieve itching (antipruritics) and bile acid sequesterants (cholestyramine), antibiotics to treat infections, and vitamin supplements, as people with PSC are often deficient in vitamin A, vitamin D, and vitamin K.
In some cases, ERCP, which may involve stenting of the common bile duct, may be necessary in order to open major blockages (dominant strictures).
Liver transplantation (including live transplants whereby a portion of a living donor is given to the recipient) is an option if the liver begins to fail.
See also
- Bilirubin
- Child-Pugh score
- Cholangiocarcinoma
- Liver function tests
- Primary biliary cirrhosis
- Alagille syndrome
- Progressive familial intrahepatic cholestasis
- Walter Payton (died of primary sclerosing cholangitis)
External links
- Additional Literature about PSC
- Link to PSC Partners, a nonprofit foundation for PSC patients and caregivers
- PSC Trust is a medical research charity
- Liver Families, a pediatric liver support group
- The Morgan Foundation for the Study of PSC