Leg pain

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Common Causes

• Arterial thromboembolism
• Arthritis
• Autoimmune vascular disorders such as vasculitis
• Baker's cyst
• Cholesterol embolism
• Chronic venous insufficiency
• Connective tissue disease
• Coxsackie B
• Deep Vein Thrombosis (DVT)
• Drugs, toxins
• Hypocalcemia
• Hypokalemia
• Hyponatremia
• Leptospirosis
• Ligament damage
• Lumbar canal stenosis or spinal stenosis
• Muscle or tendon strain
• Night cramps
• Obliterating endarteritis
• Peripheral neuropathy
• Peripheral vascular disease
• Plexopathy
• Primary varicosis
• Radiculopathy
• Restless Leg Syndrome
• Venous thromboembolism (VTE)

Complete Differential Diagnosis of the causes of Leg pain

(By organ system)

Cardiovascular	Aortoiliac occlusive disease,Cholesterol Emboli Syndrome,Deep Vein Thrombosis,Peripheral Arterial Disease,Thrombophlebitis,Varicose veins
Chemical / poisoning	No underlying causes
Dermatologic	Behect's disease
Drug Side Effect	Abatacept Injection,Acebutolol,Acitretin,Aldesleukin,Alendronate,Allopurinol,Amikacin Sulfate Injection,Anagrelide,Anastrozole,Aripiprazole,Atazanavir,Atenolol,Atorvastatin,Bevacizumab Injection,Bortezomib,Buspirone,Capecitabine,Celecoxib,Celiac disease,Clofarabine Injection,Clonazepam,Clopidogrel,Cortisol,Darbepoetin Alfa,Docetaxel,Epoetin Alfa Injection,Ethacrynic Acid,Etidronate,Ezetimibe,Fenofibrate,Filgrastim,Fluvastatin,Gabapentin,Galantamine,Glatiramer Injection,Ibandronate,Iloprost,Imatinib,Infliximab Injection,Interferon Alfa-2a and Alfa-2b Injection,Interferon Alfacon-1 Injection,Interferon beta-1a Intramuscular Injection,Interferon Beta-1b Injection,Interferon Gamma-1b Injection,Lamivudine,Latanoprost,Leflunomide,Letrozole,Leuprolide,Lovastatin,Methimazole,Methylergonovine,Methylprednisolone,Mifepristone,Natalizumab injection ,Ofloxacin ,Paclitaxel,Peginterferon alfa-2a,Prednisone,Pyrazinamide,Quinupristin dalfopristin,Ribavirin,Rofecoxib,Rosiglitazone,Rosuvastatin,Sunitinib ,Tadalafil ,Tamsulosin ,Telbivudine ,Temozolomide ,Terbutaline,Teriparatide,Tiotropium,Torsemide,Valganciclovir,Valsartan,Vancomycin,Vinblastine,Vincristine,Zalcitabine,Ziprasidone,Zolmitriptan,Zolpidem,
Ear Nose Throat	No underlying causes
Endocrine	Hyperparathyroidism,Primary hyperparathyroidism
Environmental	No underlying causes
Gastroenterologic	Ulcerative colitis
Genetic	Fairbanks disease,Familial Mediterranean fever,Mitochondrial trifunctional protein deficiency,Osteogenesis imperfecta,Hereditary multiple exostoses,Recessive multiple epiphyseal dysplasia,Farber disease
Hematologic	Erdheim-Chester disease,Leukemia,Lymphangiomatosis,Multiple myeloma,Phlebitis,Phlegmasia cerulea dolens,Thrombocytosis,Acute lymphoblastic leukemia,Acute myeloid leukemia,Acute promyelocytic leukemia,Cholesterol Embolism
Iatrogenic	No underlying causes
Infectious Disease	Bacterial : Cellulitis,Q Fever,Lassa Fever,Lemierre's Syndrome Viral : Parvovirus,Poliomyelitis,Rocky Mountain spotted fever,Acquired Immune Deficiency Syndrome,Coxsackie B
Musculoskeletal / Ortho	Athlete's foot,Baker's cyst,Bone tumor,Buerger's disease,Chondroblastoma,Chondromalacia patellae,Chondrosarcoma,Gout,Hereditary multiple exostoses,Ledderhose's disease,Legg-Calve-Perthes syndrome,Morton's toe,Myofascial Pain Syndrome,Myositis ossificans,Osteochondrosis,Paget's disease of bone,Pes anserinus (leg),Pigmented villonodular synovitis,Prepatellar bursitis,Recessive multiple epiphyseal dysplasia,Retropatellar Pain Syndrome,Sciatica,Synovial osteochondromatosis,Tenosynovitis,Erythromelagia,Ewing's sarcoma,Giant cell tumor of bone,Osteoporosis,Still's disease,Fairbanks disease,Osteogenesis imperfecta
Neurologic	Amyotrophic Lateral Sclerosis,Anterior spinal artery syndrome,Erythromelagia,Meralgia paraesthetica,Peripheral Neuropathy
Nutritional / Metabolic	Acute Intermittent Porphyria,Farber disease,Glycogen storage disease type V,Hypercalcemia,Mucopolysaccharidosis,Osteomalacia,Hypocalcemia,Hypokalemia,Hyponatremia
Obstetric/Gynecologic	No underlying causes
Oncologic	Acute lymphoblastic leukemia,Acute myeloid leukemia,Acute promyelocytic leukemia,Ewing's sarcoma,Giant cell tumor of bone,Osteochondroma,Osteoma,Osteosarcoma,Leukemia,Lymphangiomatosis,Chondroblastoma,Chondrosarcoma
Opthalmologic	Behect's disease
Overdose / Toxicity	No underlying causes
Psychiatric	Pain disorder
Pulmonary	No underlying causes
Renal / Electrolyte	Hypercalcemia
Rheum / Immune / Allergy	Rheumatology : Ankylosing Spondylitis,Behcet's disease,Caplan's Syndrome,Fibromyalgia,Osteoarthritis,Osteoporosis,Polymyalgia Rheumatica,Rheumatoid arthritis,Still's disease, Gout Immunology : Systemic lupus erythematosus,Ulcerative colitis,Vasculitis,Graft-versus-host disease,Familial Mediterranean fever
Sexual	No underlying causes
Trauma	No underlying causes
Urologic	No underlying causes
Dental	No underlying causes
Miscellaneous	Phantom pain

(In alphabetical order):

1. Abatacept Injection
2. Acebutolol
3. Acitretin
4. Acquired Immune Deficiency Syndrome
5. Acute Intermittent Porphyria
6. Acute lymphoblastic leukemia
7. Acute myeloid leukemia
8. Acute promyelocytic leukemia
9. Aldesleukin
10. Alendronate
11. Allopurinol
12. Amikacin Sulfate Injection
13. Amyotrophic Lateral Sclerosis
14. Anagrelide
15. Anastrozole
16. Ankylosing Spondylitis
17. Anterior spinal artery syndrome
18. Aortoiliac occlusive disease
19. Aripiprazole
20. Atazanavir
21. Atenolol
22. Athlete's foot
23. Atorvastatin
24. Baker's cyst
25. Behcet's disease
26. Bevacizumab Injection
27. Bone tumor
28. Bortezomib
29. Buerger's disease
30. Buspirone
31. Capecitabine
32. Caplan's Syndrome
33. Celecoxib
34. Celiac disease
35. Cellulitis
36. Cholesterol Emboli Syndrome
37. Chondroblastoma
38. Chondromalacia patellae
39. Chondrosarcoma
40. Clofarabine Injection
41. Clonazepam
42. Clopidogrel
43. Cortisol
44. Darbepoetin Alfa Injection
45. Deep Vein Thrombosis
46. Docetaxel
47. Epoetin Alfa Injection
48. Erdheim-Chester disease
49. Erythromelagia
50. Ethacrynic Acid
51. Etidronate
52. Ewing's sarcoma
53. Ezetimibe
54. Fairbanks disease
55. Familial Mediterranean fever
56. Farber disease
57. Fenofibrate
58. Fibromyalgia
59. Filgrastim
60. Fluvastatin
61. Gabapentin
62. Galantamine
63. Giant cell tumor of bone
64. Glatiramer Injection
65. Glycogen storage disease type V
66. Gout
67. Graft-versus-host disease
68. Hereditary multiple exostoses
69. Hypercalcemia
70. Hypercalcemia
71. Hyperparathyroidism
72. Ibandronate
73. Iloprost
74. Imatinib
75. Infliximab Injection
76. Interferon Alfa-2a and Alfa-2b Injection
77. Interferon Alfacon-1 Injection
78. Interferon beta-1a Intramuscular Injection
79. Interferon Beta-1b Injection
80. Interferon Gamma-1b Injection
81. Lamivudine
82. Lassa Fever
83. Latanoprost
84. Ledderhose's disease
85. Leflunomide
86. Legg-Calve-Perthes syndrome
87. Lemierre's Syndrome
88. Letrozole
89. Leukemia
90. Leuprolide
91. Lovastatin
92. Lymphangiomatosis
93. Meralgia paraesthetica
94. Methimazole
95. Methylergonovine Oral
96. Methylprednisolone Oral
97. Mifepristone
98. Mitochondrial trifunctional protein deficiency
99. Morton's toe
100. Mucopolysaccharidosis
101. Multiple myeloma
102. Myofascial Pain Syndrome
103. Myositis ossificans
104. Natalizumab injection
105. Ofloxacin
106. Osteoarthritis
107. Osteochondroma
108. Osteochondrosis
109. Osteogenesis imperfecta
110. Osteoma
111. Osteomalacia
112. Osteoporosis
113. Osteosarcoma
114. Paclitaxel
115. Paget's disease of bone
116. Pain disorder
117. Parvovirus
118. Peginterferon alfa-2a
119. Peripheral Arterial Disease
120. Peripheral Neuropathy
121. Pes anserinus (leg)
122. Phantom pain
123. Phlebitis
124. Phlegmasia cerulea dolens
125. Pigmented villonodular synovitis
126. Poliomyelitis
127. Polymyalgia Rheumatica
128. Prednisone
129. Prepatellar bursitis
130. Primary hyperparathyroidism
131. Pyrazinamide
132. Q Fever
133. Quinupristin and dalfopristin injection
134. Recessive multiple epiphyseal dysplasia
135. Retropatellar Pain Syndrome
136. Rheumatoid arthritis
137. Ribavirin
138. Rocky Mountain spotted fever
139. Rofecoxib
140. Rosiglitazone
141. Rosuvastatin
142. Sciatica
143. Still's disease
144. Sunitinib
145. Synovial osteochondromatosis
146. Systemic lupus erythematosus
147. Tadalafil
148. Tamsulosin
149. Telbivudine
150. Temozolomide
151. Tenosynovitis
152. Terbutaline
153. Teriparatide (rDNA origin) Injection
154. Thrombocytosis
155. Thrombophlebitis
156. Tiotropium Oral Inhalation
157. Torsemide Injection
158. Ulcerative colitis
159. Valganciclovir
160. Valsartan
161. Vancomycin
162. Varicose veins
163. Vasculitis
164. Vinblastine
165. Vincristine
166. Zalcitabine
167. Ziprasidone
168. Zolmitriptan Nasal
169. Zolpidem

References

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