Papular purpuric gloves and socks syndrome

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Raviteja Guddeti, M.B.B.S. [2]

Synonyms and keywords: PPGSS

Overview

Papular purpuric gloves and socks syndrome (PPGSS) is an uncommon cutaneous condition with a typical purpuric exanthem limited to hands and feet.

Causes

• An association with parvovirus B19 has been described.

Epidemiology and Demographics

• PPGSS occurs primarily in teenagers and young adults.

Diagnosis

Symptoms

PPGSS is characterized by

• Pruritus
• Fever

Physical Examination

Extremities

• Edema
• Erythema of the hands and feet,

Laboratory Findings

• Positive serology for Parvovirus B19.