Chagas disease natural history
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
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Overview
Natural history
Complications
Complications of Chagas disease include:
- Myocarditis
- Meningoencephalitis
- Congestive heart failure
- Apical aneurysm
- Thromboembolism
- Sudden death
- Esophagitis
- Esophageal cancer
- Fecaloma
- Volvulus of sigmoid colon
Prognosis
An index for classification of patients who have Chagas' disease was published in the August 24, 2006 edition of the New England Journal of Medicine.[1] Based on over 500 patients, this index includes clinical aspects, X-ray findings, EKG, echocardiography and Holter.
| Risk factor | points |
|---|---|
| NYHA class III or IV | 5 |
| Cardiomegaly | 5 |
| Wall motion abnormalities | 3 |
| non-sustained ventricular tachycardia | 3 |
| low voltage on ECG | 2 |
| male sex | 2 |
| Total points | Risk of death in 10 years |
|---|---|
| 0–6 | 10% |
| 7–11 | 40% |
| 12–20 | 85% |
References
- ↑ Rassi A Jr, Rassi A, Little W, Xavier S, Rassi S, Rassi A, Rassi G, Hasslocher-Moreno A, Sousa A, Scanavacca M (2006). "Development and validation of a risk score for predicting death in Chagas' heart disease". N Engl J Med. 355 (8): 799–808. PMID 16928995.