Amsacrine

Amsacrine

File:Amsacrine.svg
Clinical data
ATC code	L01XX01 (WHO)
Pharmacokinetic data
Protein binding	96 to 98%
Elimination half-life	8-9 hours
Identifiers
IUPAC name N-(4-(acridin-9-ylamino)-3-methoxyphenyl)methanesulfonamide
CAS Number	51264-14-3
PubChem CID	2179
DrugBank	APRD00064
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}
Chemical and physical data
Formula	C21H19N3O3S
Molar mass	393.46 g/mol

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Overview

Amsacrine is an antineoplastic agent. Its planar fused ring system can intercalate into the DNA of tumor cells, thereby altering the major and minor groove proportions. These alterations to DNA structure inhibit both DNA replication and transcription by reducing association between the affected DNA and: DNA polymerase, RNA polymerase and transcription factors.

Amsacrine also expresses topoisomerase inhibitor activity, specifically inhibiting topoisomerase II (compares with the better known agent etoposide).