Cefradine

Cefradine

Clinical data
Routes of administration	Oral, IM, IV
ATC code	J01DB09 (WHO)
Legal status
Legal status	In general: ℞ (Prescription only)
Pharmacokinetic data
Bioavailability	Well absorbed
Protein binding	<10%
Metabolism	Nil
Elimination half-life	0.9 hours
Excretion	Renal, unchanged
Identifiers
IUPAC name (6R,7R)-7-{[(2R)-2-amino-2-(1-cyclohexa-1,4- dienyl)acetyl]amino}-3-methyl-8-oxo-5-thia- 1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
CAS Number	38821-53-3
PubChem CID	38103
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}
Chemical and physical data
Formula	C16H19N3O4S
Molar mass	349.406 g/mol

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Overview

Cefradine (INN) or cephradine (former BAN) is a first generation cephalosporin antibiotic.

Indications

It has similar spectrum of activity to cefalexin.

Dosage

Dosage by mouth for adults is 250–500 mg every 6 hours, or 500 mg to 1 g every 12 hours. In severe infections up to 1 g every 6 hours may be used. Dosages for children are based upon their weight with 25–50 mg/kg total daily dose given in 2–4 divided doses.

Formulations

Caspules containing 250 mg or 500 mg, Syrup containing 250 mg/5 ml, or vials for injection containing 500 mg or 1 g.

References

• British National Formulary 45 March 2003