Cycloserine

Cycloserine

Clinical data
Pregnancy category	C
ATC code	J04AB01 (WHO)
Identifiers
IUPAC name 4-aminoisoxazolidin-3-one
CAS Number	68-41-7
PubChem CID	401
DrugBank	APRD00894
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}
Chemical and physical data
Formula	C3H6N2O2
Molar mass	102.092 g/mol

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Evidence Based Medicine
Cochrane Collaboration on Cycloserine Bandolier on Cycloserine TRIP on Cycloserine
Clinical Trials
Ongoing Trials on Cycloserine at Clinical Trials.gov Trial results on Cycloserine Clinical Trials on Cycloserine at Google
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Definitions of Cycloserine
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Experimental / Informatics
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Cycloserine is an oral broad spectrum antibiotic effective against tuberculosis, by inhibiting cell wall synthesis of TB bacilli at early stage of peptidoglycan synthesis. For the treatment against tuberculosis, it is classified as a second line drug.

It is also being trialed for treatment of phobias as well as an adjuvant to conventional treatments for depression, obsessive-compulsive disorder and schizophrenia.

The side effects are mainly CNS manifestations i.e. headache, irritability, depression, convulsions. Co-administration of pyridoxine can reduce the incidence of some of the CNS side effects(e.g. convulsions).

These psychotropic responses are related to D-cycloserine's action as a partial agonist of the neuronal NMDA receptor for glutamate and have been examined in implications with sensory-related fear extinction in the amygdala. See Michael Davis, Barbara Rothbaum, Kerry Ressler et al. and their work with PTSD at Emory University's School of Medicine.