epsilon-amanitin

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ε-Amanitin

File:Epsilon-amanitin structure.png
File:Epsilon amanitine 3d structure.png
Names
Other names Amanine
Identifiers
CAS Number	21705-02-2
3D model (JSmol)	Interactive image
ECHA InfoCard
PubChem CID	30508
SMILES O=C(NCC(N[C@@](C(NCC(N[C@@H](C3)C(N[C@@H](CC(O)=O)C(N5[C@H]4C[C@@H](O)C5)=O)=O)=O)=O)([H])[C@@H](C)CC)=O)[C@H](CC1=C(S3=O)NC2=C1C=CC(O)=C2)NC([C@@]([C@@H](C)[C@@H](O)C)([H])N[C@@]4=O)=O
Properties
Chemical formula	C39H53N9O14S
Molar mass	903.96 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

epsilon-Amanitin or ε-amanitin is a cyclic peptide. It is an amatoxin, all of which are found in several members of the Amanita genus of mushrooms. The oral of ε-Amanitin is approximately 0.1 mg/kg.

Toxicology

Like other amatoxins, ε-amanitin an inhibitor of RNA polymerase II. Upon ingestion, it binds to the RNA polymerase II enzyme which completely prevents mRNA synthesis, effectively causing cytolysis of hepatocytes (liver cells) and kidney cells.

See also

• Mushroom poisoning

External links

• Amatoxins REVISED
• Poisonous Mushrooms (German)