Mexiletine

Mexiletine

Clinical data
Pregnancy category	AU: B1 US: C (Risk not ruled out)
Routes of administration	Oral, IV
ATC code	C01BB02 (WHO)
Legal status
Legal status	UK: POM (Prescription only) US: ℞-only
Pharmacokinetic data
Bioavailability	90%
Protein binding	50-60%
Metabolism	Hepatic (CYP2D6 and 1A2- mediated)
Elimination half-life	10-12 hours
Excretion	Renal (10%)
Identifiers
IUPAC name 1-(2,6-dimethylphenoxy)propan-2-amine
CAS Number	31828-71-4
PubChem CID	4178
DrugBank	APRD00242
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}
Chemical and physical data
Formula	C11H17NO
Molar mass	179.259 g/mol

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Overview

Mexiletine (INN, sold under the trade name Mexitil®) belongs to the Class IB anti-arrhythmic group of medicines. It is used to treat arrhythmias within the heart - or seriously irregular heartbeats. It slows nerve impulses in the heart and makes the heart tissue less sensitive. Dizziness, heartburn, nausea, nervousness, trembling, unsteadiness are common side effects. It is available in injection and capsule form.

Class IB antiarrhythmics decrease action potential duration by shortening the repolarization phase. This is achieved by blocking sodium channels[3].

Mexiletine may also be of use in patients experiencing refractory pain. (Sweetman, 2002) and is also effective for treating muscle stiffness resulting from myotonia congenita (Thomsen disease)

External links

• MedlinePlus Drug Information: Mexiletine

References

• Peck T (2004). Pharmacology for Anaesthesia and Intensive Care (2nd ed. ed.). Cambridge University Press. ISBN 0-521-68794-2. CS1 maint: Extra text (link)
• Sweetman S (ed.) (2002). Martindale: The complete drug reference (33rd ed. ed.). London: Pharmaceutical Press. ISBN 0-85369-499-0.CS1 maint: Extra text: authors list (link) CS1 maint: Extra text (link)

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