Mometasone furoate detailed information

Mometasone furoate detailed information

Clinical data
Routes of administration	topical, nasal
ATC code	D07AC13 (WHO) D07XC03 (WHO), R01AD09 (WHO), R03BA07 (WHO)
Pharmacokinetic data
Bioavailability	Nasal spray is virtually undetectable in plasma
Protein binding	98% to 99%
Metabolism	hepatic
Elimination half-life	5.8 hours
Identifiers
IUPAC name (9R,10S,11S,13S,14S,16R,17R)-9-chloro- 17-(2-chloroacetyl)-11-hydroxy-10,13,16- trimethyl- 3-oxo-6,7,8,9,10,11,12,13,14,15,16,17- dodecahydro-3H-cyclopenta[a]phenanthren- 17-yl furan-2-carboxylate
CAS Number	105102-22-5 83919-23-7 as Furoate
PubChem CID	123620
DrugBank	APRD00289
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}
Chemical and physical data
Formula	C22H28Cl2O4 for Mometasone C27H30O6Cl2 as Furoate
Molar mass	427.361 g/mol

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Overview

Mometasone furoate (also referred to as Mometasone) is a moderately potent glucocorticoid steroid used in the treatment of inflammatory skin disorders (such as eczema and psoriasis), allergic rhinitis (such as hay fever), and asthma for patients unresponsive to less potent corticosteroids. In terms of steroid strength, it is more potent than hydrocortisone, and less potent than dexamethasone.

Schering-Plough markets the medication under the following brand names; Elocon (Elocom) as a cream or ointment for skin conditions, Nasonex as a nasal spray for upper respiratory conditions, Asmanex Twisthaler as a dry powder inhaler (DPI) for lower respiratory conditions.

External links

• Mometasone Furoate (Medline)
• Nasonex Home page
• Asmanex Home page

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