Nalidixic acid

Nalidixic acid

Clinical data
Pregnancy category	B U.S.
Routes of administration	Oral
ATC code	J01MB02 (WHO)
Pharmacokinetic data
Protein binding	90%
Metabolism	Partially Hepatic
Elimination half-life	6-7 hours, significantly longer in renal impairment
Identifiers
IUPAC name 1-ethyl-7-methyl-4-oxo-[1,8]naphthyridine-3-carboxylic acid
CAS Number	389-08-2
PubChem CID	4421
DrugBank	APRD01133
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}
Chemical and physical data
Formula	C12H12N2O3
Molar mass	232.235 g/mol

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Nalidixic acid is the basis for quinolone antibiotics.

Nalidixic acid is effective against both gram-positive and gram-negative bacteria. In lower concentrations, it acts bacteriostatically (that is, it inhibits growth and reproduction). In higher concentrations, it is bactericidal, meaning that it kills bacteria instead of merely inhibiting their growth.

It is especially used in treating urinary tract infections, caused for example by Escherichia coli, Proteus, Shigella, Enterobacter and Klebsiella.

External links

• Template:MedlinePlusDrugInfo
• HealthDigest.org: Nalidixic acid

See also

• DNA gyrase