Sulbactam

Sulbactam

File:Sulbactam.svg
Clinical data
Routes of administration	Injection
ATC code	J01CG01 (WHO)
Legal status
Legal status	UK: POM (Prescription only)
Pharmacokinetic data
Bioavailability	1
Excretion	Kidneys?
Identifiers
IUPAC name (2R,5R)-3,3-dimethyl-4,4,7-trioxo-4λ6-thia-1- azabicyclo[3.2.0]heptane-2-carboxylic acid
CAS Number	68373-14-8
PubChem CID	130313
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}
Chemical and physical data
Formula	C8H11NO5S
Molar mass	233.243 g/mol

WikiDoc Resources for Sulbactam
Articles
Most recent articles on Sulbactam Most cited articles on Sulbactam Review articles on Sulbactam Articles on Sulbactam in N Eng J Med, Lancet, BMJ
Media
Powerpoint slides on Sulbactam Images of Sulbactam Photos of Sulbactam Podcasts & MP3s on Sulbactam Videos on Sulbactam
Evidence Based Medicine
Cochrane Collaboration on Sulbactam Bandolier on Sulbactam TRIP on Sulbactam
Clinical Trials
Ongoing Trials on Sulbactam at Clinical Trials.gov Trial results on Sulbactam Clinical Trials on Sulbactam at Google
Guidelines / Policies / Govt
US National Guidelines Clearinghouse on Sulbactam NICE Guidance on Sulbactam NHS PRODIGY Guidance FDA on Sulbactam CDC on Sulbactam
Books
Books on Sulbactam
News
Sulbactam in the news Be alerted to news on Sulbactam News trends on Sulbactam
Commentary
Blogs on Sulbactam
Definitions
Definitions of Sulbactam
Patient Resources / Community
Patient resources on Sulbactam Discussion groups on Sulbactam Patient Handouts on Sulbactam Directions to Hospitals Treating Sulbactam Risk calculators and risk factors for Sulbactam
Healthcare Provider Resources
Symptoms of Sulbactam Causes & Risk Factors for Sulbactam Diagnostic studies for Sulbactam Treatment of Sulbactam
Continuing Medical Education (CME)
CME Programs on Sulbactam
International
Sulbactam en Espanol Sulbactam en Francais
Business
Sulbactam in the Marketplace Patents on Sulbactam
Experimental / Informatics
List of terms related to Sulbactam

Please Take Over This Page and Apply to be Editor-In-Chief for this topic: There can be one or more than one Editor-In-Chief. You may also apply to be an Associate Editor-In-Chief of one of the subtopics below. Please mail us [1] to indicate your interest in serving either as an Editor-In-Chief of the entire topic or as an Associate Editor-In-Chief for a subtopic. Please be sure to attach your CV and or biographical sketch.

Sulbactam is a molecule which is given in combination with beta-lactam antibiotics to inhibit beta-lactamase, an enzyme produced by bacteria that destroys the antibiotics. Sulbactam is an irreversible inhibitor of beta-lactamase; it binds the enzyme and does not allow it to interact with the antibiotic. Sulbactam is able to inhibit the most common forms of beta-lactamase but is not able to interact with the ampC cephalosporinase. Thus, it confers little protection against bacteria such as Pseudomonas aeruginosa, Citrobacter, Enterobacter, and Serratia, which often express this gene. In the United States, sulbactam is combined to form cefoperazone/sulbactam and ampicillin/sulbactam. It does possess some antibacterial activity when administered alone, but it is too weak to have any clinical importance. Its use in the UK is restricted to hospitals.

References

• Singh GS. Beta-lactams in the new millennium. Part-II: cephems, oxacephems, penams and sulbactam. Mini Rev Med Chem. 2004 Jan;4(1):93-109. Review. PMID 14754446