Terlipressin

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Terlipressin
Clinical data
Routes of; administration	IV
ATC code	H01BA04 (WHO) ;
Pharmacokinetic data
Protein binding	~30%
Identifiers
	IUPAC name (2S)-1-[(4S,7S,10S,13S,16S,19S)-19-[[2-; [[2-[(2-Aminoacetyl)amino]acetyl]amino]; acetyl]amino]-13-benzyl-10-(2-carbamoylethyl)-; 7-(carbamoylmethyl)-16-[(4-hydroxyphenyl); methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8,; 11,14,17-pentazacycloicosane-4-carbonyl]-N-; [(1S)-5-amino-1-(carbamoylmethylcarbamoyl); pentyl]pyrrolidine-2-carboxamide;
CAS Number	14636-12-5;
PubChem CID	72081;
DrugBank	EXPT03310;
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C52H74N16O15S2
Molar mass	1227.37 g/mol

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Terlipressin is an analogue of vasopressin used as a vasoactive drug in the management of hypotension. It has been found to be effective when norepinephrine does not help.

Indications for use include norepinephrine-resistant septic shock^[1] and hepatorenal syndrome.^[2] In addition, it is used in bleeding esophageal varices.^[3]
Terlipressin is marketed under the brand name Glypressin (Ferring Pharmaceuticals).

References

↑ O'Brien A, Clapp L, Singer M (2002). "Terlipressin for norepinephrine-resistant septic shock". Lancet. 359 (9313): 1209&ndash, 10. PMID 11955542.
↑ Uriz J, Ginès P, Cárdenas A, Sort P, Jiménez W, Salmerón J, Bataller R, Mas A, Navasa M, Arroyo V, Rodés J (2000). "Terlipressin plus albumin infusion: an effective and safe therapy of hepatorenal syndrome". J Hepatol. 33 (1): 43&ndash, 8. PMID 10905585.
↑ Ioannou G, Doust J, Rockey D. "Terlipressin for acute esophageal variceal hemorrhage". Cochrane Database Syst Rev: CD002147. PMID 12535432.

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[OBrien-1] O'Brien A, Clapp L, Singer M (2002). "Terlipressin for norepinephrine-resistant septic shock". Lancet. 359 (9313): 1209&ndash, 10. PMID 11955542.

[Uriz-2] Uriz J, Ginès P, Cárdenas A, Sort P, Jiménez W, Salmerón J, Bataller R, Mas A, Navasa M, Arroyo V, Rodés J (2000). "Terlipressin plus albumin infusion: an effective and safe therapy of hepatorenal syndrome". J Hepatol. 33 (1): 43&ndash, 8. PMID 10905585.

[Ioannou-3] Ioannou G, Doust J, Rockey D. "Terlipressin for acute esophageal variceal hemorrhage". Cochrane Database Syst Rev: CD002147. PMID 12535432.

[1]

[2]

[3]

Terlipressin

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Clinical data

Routes of administration	IV
ATC code	H01BA04 (WHO)
Pharmacokinetic data
Protein binding	~30%
Identifiers
IUPAC name (2S)-1-[(4S,7S,10S,13S,16S,19S)-19-[[2- [[2-[(2-Aminoacetyl)amino]acetyl]amino] acetyl]amino]-13-benzyl-10-(2-carbamoylethyl)- 7-(carbamoylmethyl)-16-[(4-hydroxyphenyl) methyl]-6,9,12,15,18-pentaoxo-1,2-dithia-5,8, 11,14,17-pentazacycloicosane-4-carbonyl]-N- [(1S)-5-amino-1-(carbamoylmethylcarbamoyl) pentyl]pyrrolidine-2-carboxamide
CAS Number	14636-12-5
PubChem CID	72081
DrugBank	EXPT03310
E number	{{#property:P628}}
ECHA InfoCard	{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
Formula	C₅₂H₇₄N₁₆O₁₅S₂
Molar mass	1227.37 g/mol

Terlipressin

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