Viminol

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Viminol
Clinical data
SynonymsViminol, Dividol
Routes of
administration		Oral
ATC code
Legal status
Legal status
  • In general: ℞ (Prescription only)
Identifiers
CAS Number
PubChem CID
E number{{#property:P628}}
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Chemical and physical data
FormulaC21H31ClN2O
Molar mass362.94 g/mol

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

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Overview

Viminol (marketed under the brandname Dividol) is a drug which is an opioid analgesic. It has an unusual chemical structure that is not similar to other opioids.[1][2]

Viminol has both antitussive (cough suppressing) and analgesic (pain reducing) effects. It has six different stereoisomers which have varying properties, with the R2 isomer being a μ-opioid full agonist slightly more potent than morphine, while the S2 isomer is an antagonist.[3] Since vimonol is supplied as a racemic mixture of isomers, the overall effect produces a mixed agonist-antagonist profile similar to that of opioids such as pentazocine, although with somewhat less side effects.[4]

Viminol has similar effects to other opioids, and produces analgesia, sedation and euphoria.

Side Effects

Side effects are similar to other opiods, and can include:

However, since viminol is supplied as a racemic mixture of agonist and antagonist isomers, the abuse potential and respiratory depression tends to be less than that of μ-opioid full agonist drugs.

References

  1. ↑ Contri AM. Chromatographic separation of diastereoisomers of aminoalcohol salts and their densitometric determination. (Italian). Il Farmaco. 1981 Apr;36(4):215-22.
  2. ↑ Neto JM, Murad JE, Monteiro SS. Psychopharmacological properties of the viminol-p-hydroxybenzoate. Revista Brasileira de Pesquisas Medicas e Biologicas. 1977 Dec;10(6):361-8.
  3. ↑ Shook JE, Kallman MJ, Dewey WL. The discriminative stimulus properties of the R2 isomer of viminol. Pharmacology, Biochemistry and Behaviour. 1984 Jan;20(1):59-62.
  4. ↑ Cinelli M, Costa V, Ventresca GP, Lodola E. Viminol R2 analgesic activity in patients with postoperative pain: comparison with pentazocine. International Journal of Clinical Pharmacology, Therapy and Toxicology. 1986 May;24(5):232-5.


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