Henoch-Schönlein purpura other diagnostic studies

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Skin biopsy

If there is doubt about the cause of the skin lesions, a biopsy of the skin may be performed to distinguish the purpura from other diseases that cause purpura (such as vasculitis due to cryoglobulinemia); on microscopy the appearances are of ahypersensitivity vasculitis and immunofluorescence demonstrates IgA and C3 (a protein of thecomplement system) in the blood vessel wall.