Cushing's syndrome history and symptoms
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
History
Symptoms
Symptoms include
- Rapid weight gain, particularly of the trunk and face with sparing of the limbs (central obesity),
- A round face often referred to as a "moon face",
- Excess sweating,
- Telangiectasia (dilation of capillaries),
- The excess cortisol may also affect other endocrine systems and cause, for example,
- Insomnia
- Reduced libido
- Impotence
- Amenorrhoea
- Infertility.
- Patients frequently suffer various psychological disturbances, ranging from euphoria to psychosis. Depression and anxiety are also common.[1]
Furthermore, gastrointestinal disturbances, opportunistic infections and impaired wound healing (cortisol is a stress hormone, so it depresses the immune and inflammatory responses).
Osteoporosis is also problem in Cushing's Syndrome, as mentioned before, cortisol evokes a stress-like response. The body's maintenance of bone (and other tissues) is therefore no longer one of its main priorities, so to speak.
References
- ↑ Yudofsky, Stuart C. (2007). The American Psychiatric Publishing Textbook of Neuropsychiatry and Behavioral Neurosciences (5th ed.). American Psychiatric Pub, Inc. ISBN 1585622397. Unknown parameter
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