Amyotrophic lateral sclerosis epidemiology and demographics
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Epidemiology and Demographics
- ALS is one of the most common neuromuscular diseases worldwide, and people of all races and ethnic backgrounds are affected.
- Between 1 to 2 people per 100,000 develop ALS each year . ALS most commonly strikes people between 40 and 60 years of age, but younger and older people can also develop the disease. Men are affected slightly more often than women.
Although there have been reports of several "clusters" including three American football players from the San Francisco 49ers, three soccer-playing friends in the south of England, and reports of conjugal (i.e., husband and wife) cases in the south of France[1][2][3] [4] [5], these are statistically plausible chance events. Although many authors consider ALS to be caused by a combination of genetic and environmental risk factors, so far the latter have not been firmly identified, other than a higher risk with increasing age.
References
- ↑ Rachele MG, Mascia V, Tacconi P, Dessi N, Marrosu F (1998). "Conjugal amyotrophic lateral sclerosis: a report on a couple from Sardinia, Italy". Ital J Neurol Sci. Apr;19 (2): 97–100. PMID: 10935845.
- ↑ Poloni M, Micheli A, Facchetti D, Mai R, Ceriani F (1997). "Conjugal amyotrophic lateral sclerosis: toxic clustering or change?". Ital J Neurol Sci. Apr;18 (2): 109–12. PMID: 9239532.
- ↑ Camu W, Cadilhac J, Billiard M. (1994). "Conjugal amyotrophic lateral sclerosis: a report on two couples from southern France". Neurology. Mar;44 (3 Pt 1): 547–8. PMID: 8145930.
- ↑ Cornblath DR, Kurland LT, Boylan KB, Morrison L, Radhakrishnan K, Montgomery M. (1993). "Conjugal amyotrophic lateral sclerosis: report of a young married couple". Neurology. Nov;43 (11): 2378–80. PMID: 8232960.
- ↑ Corcia P, Jafari-Schluep HF, Lardillier D, Mazyad H, Giraud P, Clavelou P, Pouget J, Camu W (2003). "A clustering of conjugal amyotrophic lateral sclerosis in southeastern France". Neurol. Apr;60 (4): 553–7. PMID: 12707069.