Huntington's disease history and symptoms

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

History and Symptoms

Although there is no sudden loss of abilities or exhibition of symptoms, there is a progressive decline.

Physicals

  • Jerky, random, uncontrollable movements called chorea athough some exhibit very slow movement and stiffness
  • Loss of determination
  • Speaking is impaired with slurred words and uncontrollable movements of the mouth
  • Eating and mobility are extremely difficult if not impossible, and full-time care is required.

Cognitive : Abilities affected are;

  • Executive function
  • Planning; cognitive flexibility
  • Rule acquisition
  • Initiating appropriate actions
  • Inhibiting inappropriate actions
  • Slurring of the words and some uncontrollable movement of the lips
  • Perceptual and spatial skills of self and surrounding environment
  • Ability to learn new skills, depending on the affected parts of the brain.

Psychopathological : Psychopathological symptoms vary more than cognitive and physical symptoms, and may include

References

  1. Mitchell IJ, Heims H, Neville EA, Rickards H. Huntington's disease patients show impaired perception of disgust in the gustatory and olfactory modalities. Journal of Neuropsychiatry and Clinical Neuroscience, 17:119-121, February 2005. PMID 15746492
  2. Sprengelmeyer R, Schroeder U, Young AW, Epplen JT. "Disgust in pre-clinical Huntington's disease: a longitudinal study." Neuropsychologia. 2006;44(4):518-33. Epub 2005 August 11. PMID 16098998
  3. PubMed search for "Huntington's disease" and "disgust"

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