Splenic marginal zone lymphoma pathophysiology

Splenic marginal zone lymphoma Microchapters
Home
Patient Information
Overview
Historical Perspective
Classification
Pathophysiology
Causes
Differentiating Splenic marginal zone lymphoma from other Diseases
Epidemiology and Demographics
Risk Factors
Screening
Natural History, Complications and Prognosis
Diagnosis
Staging
History and Symptoms
Physical Examination
Laboratory Findings
Biopsy
CT
MRI
Ultrasound
Other Imaging Findings
Other Diagnostic Studies
Treatment
Medical Therapy
Surgery
Cost-Effectiveness of Therapy
Future or Investigational Therapies
Case Studies
Case #1
Splenic marginal zone lymphoma pathophysiology On the Web
Most recent articles
Most cited articles
Review articles
CME Programs
Powerpoint slides
Images
American Roentgen Ray Society Images of Splenic marginal zone lymphoma pathophysiology All Images X-rays Echo & Ultrasound CT Images MRI
Ongoing Trials at Clinical Trials.gov
US National Guidelines Clearinghouse
NICE Guidance
FDA on Splenic marginal zone lymphoma pathophysiology
CDC on Splenic marginal zone lymphoma pathophysiology
Splenic marginal zone lymphoma pathophysiology in the news
Blogs on Splenic marginal zone lymphoma pathophysiology
Directions to Hospitals Treating Splenic marginal zone lymphoma
Risk calculators and risk factors for Splenic marginal zone lymphoma pathophysiology

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [2]

Pathophysiology

Splenic marginal zone lymphoma (SMZL) is a lymphoma comprised of B-cells that replace the normal architecture of the white pulp of the spleen. The neoplastic cells are both small lymphocytes and larger, transformed blasts, and they invade the mantle zone of splenic follicles and erode the marginal zone, ultimately invading the red pulp of the spleen. Frequently, the bone marrow and splenic hilar lymph nodes are involved along with the peripheral blood. The neoplastic cells circulating in the peripheral blood are termed villious lymphocytes due to their characteristic appearance.