Glucocorticoid resistance

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Overview

Patients can be both resistant and hypersensitive to glucocorticoids.

In glucocorticoid resistance, the target tissue is unable to respond to glucocorticoids. The lack of responsiveness can be

  1. Generalized or tissue-specific
  2. Transient or permanent
  3. Partial or complete
  4. Compensated or noncompensated.

The presence of complete glucocorticoid resistance is fatal. Absence of functional glucocorticoid receptors (GRs) in GR -/- knockout mice is associated with death within hours.

Related Key Words and Synonyms: cortisol resistance, glucocorticoid insensitivity, steroid hormone resistance, glucocorticoid receptor, steroid hormone insensitivity, overexpression of human glucocorticoid receptor beta, generalized partial end-organ insensitivity to physiologic glucocorticoid concentrations, elevations in circulating cortisol, mineralocorticoid excess, androgen excess

Epidemiology and Demographics

Risk Factors

Screening

Pathophysiology & Etiology

Molecular Biology

Genetics

Natural History

Diagnosis

Differential Diagnosis

History and Symptoms

Physical Examination

Appearance of the Patient

Vital Signs

Skin

Eyes

Ear Nose and Throat

Heart

Lungs

Abdomen

Extremities

Neurologic

Other

Laboratory Findings

Electrolyte and Biomarker Studies

Electrocardiogram

Chest X Ray

MRI and CT

Echocardiography or Ultrasound

Other Imaging Findings

Other Diagnostic Studies

Risk Stratification and Prognosis

Treatment

Pharmacotherapy

Acute Pharmacotherapies

Chronic Pharmacotherapies

Surgery and Device Based Therapy

Indications for Surgery

Pre-Operative Assessment

Post-Operative Management

Transplantation

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

"The Way I Like To Do It ..." Tips and Tricks From Clinicians Around The World

Suggested Revisions to the Current Guidelines

References

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Acknowledgements

The content on this page was first contributed by: C. Michael Gibson, M.S., M.D.

Initial content for this page in some instances came from Wikipedia

List of contributors:

Suggested Reading and Key General References

Suggested Links and Web Resources

For Patients


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