Pseudo-Cushing's syndrome

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Pseudo-Cushing's syndrome
ICD-10	E24.3

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Investigations

• Levels of cortisol and ACTH are both high
• 24-hour urinary cortisol levels are high
• Dexamethasone suppression test fails to suppress serum cortisol
• Loss of diurnal variation in cortisol levels- Loss of Diurnal Variation is seen only in true Cushing's Syndrome or Disease.
• High mean corpuscular volume and gamma-glutamyl transferase may be clues to alcoholism
• Polycystic Ovarian Syndrome should be ruled out, since PCOS has similar symptoms.

Prognosis

• Blood results and symptoms normalise rapidly on cessation of drinking or remission of depression

References

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