Thrombotic thrombocytopenic purpura overview
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Thrombotic thrombocytopenic purpura (TTP or Moschcowitz disease) is a rare disorder of the blood-coagulation system, causing multiple blood clots to form in blood vessels around the body.[1] Most cases of TTP arise from deficiency or inhibition of the enzyme ADAMTS13, which is responsible for cleaving large multimers of von Willebrand factor.[2] This leads to hemolysis and end-organ damage, and may require plasmapheresis therapy.