Danubian endemic familial nephropathy
| Danubian endemic familial nephropathy | |
| DiseasesDB | 31409 |
|---|---|
| MeSH | D001449 |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Synonyms and keywords: DEFN; Balkan endemic nephropathy; endemic nephropathy, Balkan; nephropathy, Balkan
Causes
The etiology for DEFN is currently unknown.[1]. It has recently been hypothesized that chronic exposure to dietary aristolochic acid is a major risk for DEFN. Aristolochic acid may come from Aristolochia clematitis, a plant native to the endemic region, and its seeds may comingle with wheat used for bread.[2] This theory has recently gained further support through research by Arthur P. Grollman, cancer biologist and the director of Stony Brook University's chemical biology lab in New York, and Bojan Jelaković, an associate professor at the Zagreb University School of Medicine. [3]
References
- ↑ Batuman V (2006). "Fifty years of Balkan endemic nephropathy: daunting questions, elusive answers". Kidney Int. 69 (4): 644–6. doi:10.1038/sj.ki.5000231. PMID 16467889.
- ↑ Grollman AP, Shibutani S, Moriya M; et al. (2007). "Aristolochic acid and the etiology of endemic (Balkan) nephropathy". Proc. Natl. Acad. Sci. U.S.A. 104 (29): 12129–34. doi:10.1073/pnas.0701248104. PMID 17620607.
- ↑ Julia C. Mead (2007). "Manna from hell". The Scientist. 21 (11): 44.