Fanconi syndrome (patient information)
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Fanconi syndrome |
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Fanconi syndrome On the Web |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Charmaine Patel, M.D. [2]
Overview
Fanconi syndrome is a disorder of the kidney tubes in which certain substances normally absorbed into the bloodstream by the kidneys are released into the urine instead.
What are the symptoms of Fanconi syndrome?
- Passing large amounts of urine, which can lead to dehydration
- Bone pain
- Weakness
What causes Fanconi syndrome?
Fanconi syndrome can be caused by faulty genes, or it may result later in life due to kidney damage. Sometimes the cause of Fanconi syndrome is unknown.
Common causes of Fanconi syndrome in children are genetic defects that affect the body's ability to break down certain compounds such as:
- Cystine (cystinosis)
- Fructose (fructose intolerance)
- Galactose (galactosemia)
- Glycogen (glycogen storage disease)
Cystinosis is the most common cause of Fanconi syndrome in children.
Other causes in children include:
- Exposure to heavy metals such as lead, mercury, or cadmium
- Lowe's disease, a rare genetic disorder of the eyes, brain, and kidneys
- Wilson's disease
In adults, Fanconi syndrome can be caused by various things that damage the kidneys, including:
- Certain medications, including azathioprine, cidofovir, gentamicin, and tetracycline
- Kidney transplant
- Light chain deposition disease
- Multiple myeloma
- Primary amyloidosis
Who is at highest risk?
Diagnosis
When to seek urgent medical care?
Treatment options
Where to find medical care for Fanconi syndrome?
Directions to Hospitals Treating Condition