Selye syndrome

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List of terms related to Selye syndrome

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Synonyms and keywords: Selye's syndrome; general adaptation syndrome.

Overview

Selye syndrome Eponym used to indicate the sum of all reactions – physiological changes – that follow a prolonged exposure to intense stress. The typical pathologic findings are represented by adrenal cortical hyperplasia, thymic and lymphatic involution, gastrointestinal erosion or ulcers. The first two stages are the alarm reaction and the adaptation stage. If the stressor is not removed, the exhaustion stage and death will follow.

Historical Perspective

Selye first conceived this theory in 1936 after observing the reactions of animals exposed to a variety of non-specific damaging agents.

"The non-specific response of the body to any demand made upon it."