Brugada syndrome drugs to avoid

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Generic name Brand name® Class / Clinical use References Recommendation
Ajmaline e.g.
Gilurytmal®
- more brand names here -
Antiarrhythmic Agent (1A: Na-blocker) / Arrhythmias Brugada 1997
Rolf 2003
Wolpert 2005
Bébarová 2005
Class I
Flecainide e.g.
Tambocor®
- more brand names here -
Antiarrhythmic Agent (1C: Na-blocker) / Arrhythmias Krishnan 1998
Brugada 2000
Gasparini 2003
Meregalli 2006
Stokoe 2007
Class I
Pilsicainide e.g.
Sunrhythm®
- more brand names here -
Antiarrhythmic Agent (1C: Na-blocker) / Arrhythmias Takenaka 1999
Fujiki 1999
Takagi 2002
Kimura 2004
Class I
Procainamide e.g.
Procan®
Pronestyl®
- more brand names here -
Antiarrhythmic Agent (1A: Na-blocker) / Arrhythmias Miyazaki 1996
Brugada 1997
Joshi 2007
Villemaire 1992
Class I
Propafenone e.g.
Rythmol®
- more brand names here -
Antiarrhythmic Agent (1C: Na-blocker) / Arrhythmias Matana 2000
Akdemir 2002
Hasdemir 2006
Shan 2008
Stark 1996
Class IIa

Recommendation: Class I: convincing evidence/opinion; Class IIa: evidence/opinion less clear; Class IIb: conflicting evidence/opinion; Class III: very little evidence.