Brugada syndrome drugs to avoid

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

There are certain drugs that should be avoided in patients with Brugada syndrome.

Drugs to Avoid

The following drugs should be avoided in patients with Brugada syndrome.

Generic name	Brand name®	Class / Clinical use	References	Recommendation
Ajmaline	e.g. Gilurytmal® - more brand names here -	Antiarrhythmic Agent (1A: Na-blocker) / Arrhythmias	Brugada 1997 Rolf 2003 Wolpert 2005 Bébarová 2005	Class I
Flecainide	e.g. Tambocor® - more brand names here -	Antiarrhythmic Agent (1C: Na-blocker) / Arrhythmias	Krishnan 1998 Brugada 2000 Gasparini 2003 Meregalli 2006 Stokoe 2007	Class I
Pilsicainide	e.g. Sunrhythm® - more brand names here -	Antiarrhythmic Agent (1C: Na-blocker) / Arrhythmias	Takenaka 1999 Fujiki 1999 Takagi 2002 Kimura 2004	Class I
Procainamide	e.g. Procan® Pronestyl® - more brand names here -	Antiarrhythmic Agent (1A: Na-blocker) / Arrhythmias	Miyazaki 1996 Brugada 1997 Joshi 2007 Villemaire 1992	Class I
Propafenone	e.g. Rythmol® - more brand names here -	Antiarrhythmic Agent (1C: Na-blocker) / Arrhythmias	Matana 2000 Akdemir 2002 Hasdemir 2006 Shan 2008 Stark 1996	Class IIa

Recommendation: Class I: convincing evidence/opinion; Class IIa: evidence/opinion less clear; Class IIb: conflicting evidence/opinion; Class III: very little evidence.