TREM1

Triggering receptor expressed on myeloid cells 1
File:PBB Protein TREM1 image.jpg PDB rendering based on 1q8m.
Available structures PDB Ortholog search: Template:Homologene2PDBe PDBe, Template:Homologene2uniprot RCSB List of PDB id codes 1q8m​, 1smo​
Identifiers
Symbols	TREM1 ; TREM-1
External IDs	Template:OMIM5 Template:MGI HomoloGene: 10243
Gene ontology Molecular function Template:GNF GO Cellular component Template:GNF GO Template:GNF GO Biological process Template:GNF GO Template:GNF GO
RNA expression pattern
File:PBB GE TREM1 219434 at tn.png
More reference expression data
Orthologs
Template:GNF Ortholog box
Species	Human	Mouse
Entrez	n/a	n/a
Ensembl	n/a	n/a
UniProt	n/a	n/a
RefSeq (mRNA)	n/a	n/a
RefSeq (protein)	n/a	n/a
Location (UCSC)	n/a	n/a
PubMed search	n/a	n/a

Triggering receptor expressed on myeloid cells 1, also known as TREM1, is a human gene.

Monocyte/macrophage- and neutrophil-mediated inflammatory responses can be stimulated through a variety of receptors, including G protein-linked 7-transmembrane receptors (e.g., FPR1; MIM 136537), Fc receptors (see MIM 146790), CD14 (MIM 158120) and Toll-like receptors (e.g., TLR4; MIM 603030), and cytokine receptors (e.g., IFNGR1; MIM 107470). Engagement of these receptors can also prime myeloid cells to respond to other stimuli. Myeloid cells express receptors belonging to the Ig superfamily, such as TREM1, or to the C-type lectin superfamily. Depending on their transmembrane and cytoplasmic sequence structure, these receptors have either activating (e.g., KIR2DS1; MIM 604952) or inhibitory functions (e.g., KIR2DL1; MIM 604936).[supplied by OMIM]

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K; et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. PMID 9373149.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bouchon A, Dietrich J, Colonna M (2000). "Cutting edge: inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes". J. Immunol. 164 (10): 4991–5. PMID 10799849.CS1 maint: Multiple names: authors list (link)
• Bouchon A, Facchetti F, Weigand MA, Colonna M (2001). "TREM-1 amplifies inflammation and is a crucial mediator of septic shock". Nature. 410 (6832): 1103–7. doi:10.1038/35074114. PMID 11323674.CS1 maint: Multiple names: authors list (link)
• Gingras MC, Lapillonne H, Margolin JF (2002). "TREM-1, MDL-1, and DAP12 expression is associated with a mature stage of myeloid development". Mol. Immunol. 38 (11): 817–24. PMID 11922939.CS1 maint: Multiple names: authors list (link)
• Strausberg RL, Feingold EA, Grouse LH; et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Allcock RJ, Barrow AD, Forbes S; et al. (2003). "The human TREM gene cluster at 6p21.1 encodes both activating and inhibitory single IgV domain receptors and includes NKp44". Eur. J. Immunol. 33 (2): 567–77. doi:10.1002/immu.200310033. PMID 12645956.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Bleharski JR, Kiessler V, Buonsanti C; et al. (2003). "A role for triggering receptor expressed on myeloid cells-1 in host defense during the early-induced and adaptive phases of the immune response". J. Immunol. 170 (7): 3812–8. PMID 12646648.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Colonna M, Facchetti F (2003). "TREM-1 (triggering receptor expressed on myeloid cells): a new player in acute inflammatory responses". J. Infect. Dis. 187 Suppl 2: S397–401. PMID 12792857.
• Mungall AJ, Palmer SA, Sims SK; et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. doi:10.1038/nature02055. PMID 14574404.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Radaev S, Kattah M, Rostro B; et al. (2004). "Crystal structure of the human myeloid cell activating receptor TREM-1". Structure. 11 (12): 1527–35. PMID 14656437.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Radsak MP, Salih HR, Rammensee HG, Schild H (2004). "Triggering receptor expressed on myeloid cells-1 in neutrophil inflammatory responses: differential regulation of activation and survival". J. Immunol. 172 (8): 4956–63. PMID 15067076.CS1 maint: Multiple names: authors list (link)
• Wang DY, Qin RY, Liu ZR; et al. (2004). "Expression of TREM-1 mRNA in acute pancreatitis". World J. Gastroenterol. 10 (18): 2744–6. PMID 15309732.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Kelker MS, Foss TR, Peti W; et al. (2004). "Crystal structure of human triggering receptor expressed on myeloid cells 1 (TREM-1) at 1.47 A.". J. Mol. Biol. 342 (4): 1237–48. doi:10.1016/j.jmb.2004.07.089. PMID 15351648.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Gerhard DS, Wagner L, Feingold EA; et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Knapp S, Gibot S, de Vos A; et al. (2005). "Cutting edge: expression patterns of surface and soluble triggering receptor expressed on myeloid cells-1 in human endotoxemia". J. Immunol. 173 (12): 7131–4. PMID 15585833.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• González-Roldán N, Ferat-Osorio E, Aduna-Vicente R; et al. (2006). "Expression of triggering receptor on myeloid cell 1 and histocompatibility complex molecules in sepsis and major abdominal surgery". World J. Gastroenterol. 11 (47): 7473–9. PMID 16437719.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Tzivras M, Koussoulas V, Giamarellos-Bourboulis EJ; et al. (2006). "Role of soluble triggering receptor expressed on myeloid cells in inflammatory bowel disease". World J. Gastroenterol. 12 (21): 3416–9. PMID 16733861.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Plachouras D, Routsi C, Giamarellos-Bourboulis EJ; et al. (2006). "Monocytes as a site of production of soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) in the septic host". Scand. J. Infect. Dis. 38 (10): 909–15. doi:10.1080/00365540600786523. PMID 17008237.CS1 maint: Explicit use of et al. (link) CS1 maint: Multiple names: authors list (link)
• Murakami Y, Kohsaka H, Kitasato H, Akahoshi T (2007). "Lipopolysaccharide-induced up-regulation of triggering receptor expressed on myeloid cells-1 expression on macrophages is regulated by endogenous prostaglandin E2". J. Immunol. 178 (2): 1144–50. PMID 17202378.CS1 maint: Multiple names: authors list (link)