Soy allergy

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Soy Allergy Microchapters

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Overview

Pathophysiology

Causes

Differentiating Soy Allergy from other Diseases

Epidemiology and Demographics

Risk Factors

Natural History, Complications and Prognosis

Diagnosis

History and Symptoms

Physical Examination

Laboratory Findings

Other Imaging Findings

Other Diagnostic Studies

Treatment

Medical Therapy

Primary Prevention

Secondary Prevention

Cost-Effectiveness of Therapy

Future or Investigational Therapies

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Case #1

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Synonyms and keywords: Soya allergy

Overview

Soy allergy is a type of food allergy. Soy allergy (U.S.) is one of the most common food allergies.[1]

Pathophysiology

It is a hypersensitivity to dietary substances from soy causing an overreaction of the immune system which may lead to severe physical symptoms for millions of people[2].

Food Sources of Soy Protein

Many fast-food restaurants commonly use soy protein in hamburger buns (soy flour) hamburger meat (soy protein) and hydrolyzed vegetable protein (HVP) in sauces. On their respective web sites, McDonald's, Burger King and Wendy's list soy flour as an ingredient in their hamburger buns.[3][4][5] U.S. Nutrition Information Multi-grain breads, doughnuts, doughnut mix and pancake mix commonly contain soy flour.

Some products [for reasons having to do with national regulation of soy products] don't list soy protein or soy flour on their ingredients labels, yet they still contain soy. There are still many latent issues resolving how soy should be regulated.

Studies show that most individuals who are allergic to soy protein may be able to safely consume soybean oil (not cold pressed, expeller pressed, or extruded oil) and soy lecithin, as these products do not normally contain soy protein.[6]

Product containing soy protein include:

The following food additives may contain soy protein:

  • Hydrolyzed vegetable protein (HVP)
  • Flavoring (including natural and artificial)
  • Canned chicken broth
  • Vegetable broth, gum, and starch
  • Bouillon cubes (beef, chicken, vegetable, etc.)

Epidemiology and Demographics

The Asthma and Allergy Foundation of America estimates soy is among the nine most common food allergens for pediatric and adult food allergy patients[7].

Diagnosis

History and Symptoms

Soy allergy can also manifest itself as urticaria, rash, redness (inflammation due to immune system response) and severe itching of the skin. These symptoms can happen immediately, but may also manifest a day (or even days) after consuming soy protein.[8]

Treatment

Medical Therapy

It is usually treated with an exclusion diet and vigilant avoidance of foods that may be contaminated with soy ingredients. The most severe food allergy reaction is called anaphylaxis[9] and is a medical emergency requiring immediate attention and treatment with Epinephrine. Some people who are allergic to soy protein may have an extreme allergic reaction and go into anaphylactic shock (anaphylaxis). In cases of anaphylaxis, emergency medical personnel typically administer epinephrine (available as an autoinjector, such as EpiPen) and an antihistamine such as Benadryl (diphenhydramine). In event of an allergic reaction, the victim should see a physician or immediately go to the emergency room, as anaphylaxis can be fatal if not treated immediately.

Primary Prevention

Those allergic to soy protein should always read food ingredient labels carefully and avoid any foods containing soybean, including the substances listed below. Caution should be exercised when dining at Asian restaurants or when using Asian sauces, which may contain soy.

Strict Versus Loose Soy Avoidance

Many soy-allergic individuals are sensitive to soy protein. As a result, some may be able to tolerate consumption of soy oil, which contains little soy protein. Additionally, many commercially sold foods include small amounts of soy lecithin, an emulsifier. Individuals with mild soy allergies may be able to tolerate foods with soy lecithin (for example when soy lecithin is among the last on a long list of ingredients). For individuals who are able to tolerate these small amounts of soy, allowing soy oil and lecithin creates a much less restrictive diet.

Related Chapters

References

  1. Nexus Magazine August-September, 2004; The Hidden Dangers of Soy Allergens by Kaayla T. Daniel, PhD, CCN, retrieved September 7, 2006
  2. National Institutes of Health, NIAID Allergy Statistics 2005 http://www.niaid.nih.gov/factsheets/allergystat.htm
  3. "McDonald's Nutrition Information and Ingredients", August 26, 2006, retrieved September 7, 2006
  4. McDonald's USA (11 page PDF file) "Burger King Nutrition and Ingredients" Burger King Brands Inc. USA, August, 2006, retrieved September 7, 2006
  5. Wendy's USA (6 page PDF file) "Wendy's Nutrition Facts", July 1, 2006, retrieved September 7, 2006
  6. about.com "Soy Allergy" August 13, 2006, retrieved September 7, 2006
  7. “Allergy Facts and Figures,” Asthma and Allergy Foundation of America http://www.aafa.org/display.cfm?id=9&sub=20&cont=518
  8. Nexus Magazine August-September, 2004; The Hidden Dangers of Soy Allergens by Kaayla T. Daniel, PhD, CCN, retrieved September 7, 2006
  9. National Report of the Expert Panel on Food Allergy Research, NIH-NIAID 2003 http://www3.niaid.nih.gov/about/organization/dait/PDF/june30_2003.pdf

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