Addison's disease causes

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Causes

Common Causes

Most common causes of Addison's disease include;

• Autoimmune/Idiopathic
• Tuberculosis
• AIDS
• CMV
• Hemorrhage
• Infarction
• Sarcoidosis
• Infections

Causes by Organ System

Cardiovascular	Arteritis, Hypotension, Hemorrhage, Infarction
Chemical / poisoning	No underlying causes
Dermatologic	No underlying causes
Drug Side Effect	Corticosteroid withdrawal
Ear Nose Throat	No underlying causes
Endocrine	Adrenal aplasia / hypoplasia, Adrenal metastases, After surgery of cortisol-secreting tumor, Bilateral adrenalectomy , Congenital adrenal hyperplasia, Glucocorticoid deficiency 1
Environmental	No underlying causes
Gastroenterologic	Hemochromatosis
Genetic	No underlying causes
Hematologic	Anticoagulation, Coagulopathy , Embolus, Leukemia, Lymphoma , Thrombosis
Iatrogenic	Iatrogenic, Radiation therapy
Infectious Disease	AIDS, Blastomycosis, CMV, Coccidiomycosis, Cryptococcosis, Histoplasmosis , Mycobacterium avium intracellulaire (MAI), Sepsis, Syphilis, Toxoplasmosis, Tuberculosis, Waterhouse-Friderichson syndrome
Musculoskeletal / Ortho	No underlying causes
Neurologic	Adrenoleukodystrophy, Coma
Nutritional / Metabolic	No underlying causes
Obstetric/Gynecologic	No underlying causes
Oncologic	Kaposi's sarcoma, Leukemia, Lymphoma
Opthalmologic	No underlying causes
Overdose / Toxicity	No underlying causes
Psychiatric	No underlying causes
Pulmonary	Sarcoidosis,
Renal / Electrolyte	Uremia, Waterhouse-Friderichson syndrome
Rheum / Immune / Allergy	Autoimmune, Sarcoidosis
Sexual	No underlying causes
Trauma	Trauma
Urologic	No underlying causes
Dental	No underlying causes
Miscellaneous	Amyloidosis, Idiopathic, Iatrogenic, Radiation therapy, Surgery

Causes in Alphabetical Order

• Adrenal aplasia / hypoplasia
• Adrenal metastases
• Adrenoleukodystrophy
• AIDS
• Amyloidosis
• Anticoagulation
• Arteritis
• After surgery of cortisol-secreting tumor
• Autoimmune/idiopathic
• Bilateral adrenalectomy
• Blastomycosis
• CMV
• Coagulopathy
• Coccidiomycosis
• Congenital adrenal hyperplasia
• Cryptococcosis
• Coma
• Corticosteroid withdrawal
• Drugs
• Embolus
• Glucocorticoid deficiency 1
• Hemochromatosis
• Histoplasmosis
• Hypotension
• Hemorrhage, infarction
• Iatrogenic
• Kaposi's sarcoma
• Leukemia
• Lymphoma
• Mycobacterium avium intracellulaire (MAI)
• Neonatal
• Neoplasm
• Radiation therapy
• Sarcoidosis
• Sepsis
• Surgery
• Syphilis
• Thrombosis
• Toxoplasmosis
• Trauma
• Tuberculosis (20% of all Addison's)
• Uremia
• Waterhouse-Friderichson syndrome

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