High density lipoprotein causes
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aarti Narayan, M.B.B.S [2]; Raviteja Guddeti, M.B.B.S. [3]
Causes
- HDL cholesterol is a positive cardiac risk factor if
- HDL < 35 mg/dL
- Total cholesterol to HDL ratio in > 5.0 (in men)
- Total cholesterol to HDL ratio in > 4.5 (in women)
- Negative cardiac risk factor if HDL > 60 mg/dL
Decreased
- Apolipoprotein deficiency: Hypoalphalipoproteinemia can be of three types.
- Impaired synthesis of apo A-I: apo A-I deficiency, apo A-I/C-III deficiency, apo A-I structural variants
- Increased catabolism: familial HDL deficiency or Tangier disease
- Enzymatic changes: genetic, reduced activity of lipoprotein lipase, elevated liver triglyceride lipase activity, LCAT (lecithin cholesterol acyltransferase) deficiency
- Liver disease
- Menopause[5][6]
- Obesity:High BMI is strongly associated with low serum HDl levels[2]
- Puberty in males
- Uremia[7]
- Familial combined hypolipidemia[8]
- Elevated CETP (cholesteryl ester transfer protein) activity: Polymorphism of the gene TaqIB (CETP gene) is known to be associated with variations in the plasma concentrations of CETP. A gene variant called TaqIB1 is associated with a higher CETP concentration and lower HDL-C levels in the plasma. Two other mutations that result in similar findings are A373P and R451Q.[9][10][11][12]
- Smoking
- Lack of physical exercise[2]
- High carbohydrate diet
Increased
- Drugs
- Chronic alcoholism: Alcohol consumption raises HDL cholesterol levels by increasing the transport rate of apolipoproteins A-I and A-II.
Alcohol consumption of 30–40 g/day (1–3 drinks/day) or more has been shown to increase HDL-C levels [13]
- Extensive aerobic exercise
- Alcoholic liver disease
- Weight loss: For every 1 kg weight loss serum HDL increases by 0.35 mg/dL[14]
- Hyperalphalipoproteinemia
- Oral estrogen replacement therapy
- CETP deficiency (single gene defects in 16q21)[15][16]
References
- ↑ 1.0 1.1 Sanyal D, Ghosh S, Mukherjee P, Mukherjee S, Chowdhury S (2012). "Dyslipidemia, metabolic syndrome, and liver enzymes in impaired glucose tolerance and new onset untreated, type 2 diabetes Indian subjects". Indian J Endocrinol Metab. 16 (Suppl 2): S434–5. doi:10.4103/2230-8210.104121. PMC 3603104. PMID 23565456. Unknown parameter
|month=ignored (help) - ↑ 2.0 2.1 2.2 Elme A, Utriainen M, Kellokumpu-Lehtinen P; et al. (2013). "Obesity and physical inactivity are related to impaired physical health of breast cancer survivors". Anticancer Res. 33 (4): 1595–602. PMID 23564803. Unknown parameter
|month=ignored (help) - ↑ Klein W (1992). "[Antihypertensive therapy and modification of metabolic risk factors (glucose and lipid metabolism)]". Z Kardiol (in German). 81 (6): 295–302. PMID 1353932. Unknown parameter
|month=ignored (help) - ↑ Page ST, Krauss RM, Gross C; et al. (2012). "Impact of mifepristone, a glucocorticoid/progesterone antagonist, on HDL cholesterol, HDL particle concentration, and HDL function". J. Clin. Endocrinol. Metab. 97 (5): 1598–605. doi:10.1210/jc.2011-2813. PMID 22399518. Unknown parameter
|month=ignored (help) - ↑ Jouyandeh Z, Nayebzadeh F, Qorbani M, Asadi M (2013). "Metabolic syndrome and menopause". J Diabetes Metab Disord. 12 (1): 1. doi:10.1186/2251-6581-12-1. PMC 3598172. PMID 23497470.
- ↑ Worsley R, Robinson PJ, Bell RJ, Moufarege A, Davis SR (2013). "Endogenous estrogen and androgen levels are not independent predictors of lipid levels in postmenopausal women". Menopause. doi:10.1097/GME.0b013e318279bd4a. PMID 23531683. Unknown parameter
|month=ignored (help) - ↑ Khoueiry G, Abdallah M, Saiful F; et al. (2013). "High-density lipoprotein in uremic patients: metabolism, impairment, and therapy". Int Urol Nephrol. doi:10.1007/s11255-012-0366-y. PMID 23443874. Unknown parameter
|month=ignored (help) - ↑ Minicocci I, Montali A, Robciuc MR; et al. (2012). "Mutations in the ANGPTL3 gene and familial combined hypolipidemia: a clinical and biochemical characterization". J. Clin. Endocrinol. Metab. 97 (7): E1266–75. doi:10.1210/jc.2012-1298. PMID 22659251. Unknown parameter
|month=ignored (help) - ↑ Pachocka LM, Włodarczyk M, Nowicka G, Kłosiewicz-Latoszek L, Wolańska D, Stolarska I (2012). "[CETP gene TaqIB polymorphism and plasma lipids in patients with overweight and obesity]". Rocz Panstw Zakl Hig (in Polish). 63 (2): 149–54. PMID 22928361.
- ↑ Rahimi Z, Nourozi-Rad R, Rahimi Z, Parsian A (2012). "Strong interaction between T allele of endothelial nitric oxide synthase with B1 allele of cholesteryl ester transfer protein TaqIB highly elevates the risk of coronary artery disease and type 2 diabetes mellitus". Hum. Genomics. 6: 20. doi:10.1186/1479-7364-6-20. PMC 3500247. PMID 23157875.
- ↑ Li YY, Wu XY, Xu J, Qian Y, Zhou CW, Wang B (2013). "Apo A5 -1131T/C, FgB -455G/A, -148C/T, and CETP TaqIB gene polymorphisms and coronary artery disease in the Chinese population: a meta-analysis of 15,055 subjects". Mol. Biol. Rep. 40 (2): 1997–2014. doi:10.1007/s11033-012-2257-9. PMID 23129316. Unknown parameter
|month=ignored (help) - ↑ Rejeb J, Omezzine A, Boumaiza I; et al. (2012). "Four polymorphisms of cholesteryl ester transfer protein gene and coronary stenosis in a Tunisian population". J Cardiovasc Med (Hagerstown). 13 (9): 546–53. doi:10.2459/JCM.0b013e3283569b24. PMID 22854712. Unknown parameter
|month=ignored (help) - ↑ Dai WS, LaPorte RE, Hom DL; et al. (1985). "Alcohol consumption and high density lipoprotein cholesterol concentration among alcoholics". Am. J. Epidemiol. 122 (4): 620–7. PMID 2862791. Unknown parameter
|month=ignored (help) - ↑ Farnier M (2011). "[What about HDL cholesterol?]". Rev Prat (in French). 61 (8): 1117–20. PMID 22135980. Unknown parameter
|month=ignored (help) - ↑ Chantepie S, Bochem AE, Chapman MJ, Hovingh GK, Kontush A (2012). "High-density lipoprotein (HDL) particle subpopulations in heterozygous cholesteryl ester transfer protein (CETP) deficiency: maintenance of antioxidative activity". PLoS ONE. 7 (11): e49336. doi:10.1371/journal.pone.0049336. PMC 3506611. PMID 23189141.
- ↑ Niesor EJ, von der Mark E, Calabresi L; et al. (2012). "Lipid and apoprotein composition of HDL in partial or complete CETP deficiency". Curr Vasc Pharmacol. 10 (4): 422–31. PMID 22339301. Unknown parameter
|month=ignored (help)