Cardiac amyloidosis epidemiology and demographics
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor: Lakshmi Gopalakrishnan, M.B.B.S. [2]
Overview
- 3-4% of african-americans carry the most common mutation that causes the substitution of Ile for Val at position [1] and is known to contribute to the incidence of familial amyloidotic cardiomyopathy[2]
- After the age of 60, isolated cardiac amyloidosis is four times more common among blacks than whites in the United States. In the united states, 1.3 million gene carries have been reported with an approximate 150,000 over the age of 60 at risk for cardiac deposition.[3]
References
- ↑ Dictor M, Hasserius R (1981). "Systemic amyloidosis and non-hematologic malignancy in a large autopsy series". Acta Pathologica Et Microbiologica Scandinavica. Section a, Pathology. 89 (6): 411–6. PMID 6278822. Unknown parameter
|month=ignored (help);|access-date=requires|url=(help) - ↑ Jacobson DR, Pastore R, Pool S, Malendowicz S, Kane I, Shivji A, Embury SH, Ballas SK, Buxbaum JN (1996). "Revised transthyretin Ile 122 allele frequency in African-Americans". Human Genetics. 98 (2): 236–8. PMID 8698351. Retrieved 2012-02-13. Unknown parameter
|month=ignored (help) - ↑ Jacobson DR, Pastore RD, Yaghoubian R, Kane I, Gallo G, Buck FS, Buxbaum JN (1997). "Variant-sequence transthyretin (isoleucine 122) in late-onset cardiac amyloidosis in black Americans". The New England Journal of Medicine. 336 (7): 466–73. doi:10.1056/NEJM199702133360703. PMID 9017939. Retrieved 2012-02-13. Unknown parameter
|month=ignored (help)