Magnesium and the cardiovascular system
| Magnesium and the cardiovascular system |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Template:GCC
Overview
Magnesium is the second most abundant intracellular cation after potassium and is involved in more than three hundred enzymatic reactions in the human body. It also plays important roles in mediating membrane excitability, muscle contractility, hormone receptor binding, as well as vascular tone. Bioenergetically, magnesium is crucial for utilization of adenosine triphosphate and is required for processes including glycolysis, Krebs cycle, gluconeogenesis, as well as lipid metabolism. A growing body of evidence suggests the association between magnesium depletion and a diverse spectrum of diseases including arrhythmia, hypertension, atherosclerosis, heart failure, cerebrovascular diseaseas, and metabolic syndrome.