Porokeratosis

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List of terms related to Porokeratosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Porokeratosis is a specific disorder of keratinization that is characterized histologically by the presence of a cornoid lamella, a thin column of closely stacked, parakeratotic cells extending through the stratum corneum with a thin or absent granular layer.^[1]

Historical Perspective

Porokeratosis, a disorder of epidermal keratinization was first described by Mibelli in 1893. Since then it has been classified into 6 types.

Classification

Porokeratosis may be divided into the following clinical types:

However, additional types have also been described:^[2]

Porokeratosis plantaris discreta

Pathophysiology

File:Porokeratosis - high mag.jpg

Micrograph of a case of porokeratosis showing a characteristic cornoid lamella (dark pink/red structure in the right/upper portion of the image). H&E stain.

Porokeratosis has a characteristic histomorphologic feature known as a cornoid lamella.

Causes

The aetiology of porokeratosis is still unclear. An autosomal dominant inheritance has been established for classic porokeratosis Mibelli, disseminated superficial actinic porokeratosis, disseminated superficial porokeratosis, porokeratosis palmaris et plantaris disseminata.

Risk Factors

Sun exposure
Virus infection
Immunosuppression
Radioactivity

Epidemiology and Demographics

It frequently appears in childhood but may appear at any age, especially in nonhereditary cases, with a higher incidence in males

Diagnosis

History and Symptoms

Physical Findings

Classic porokeratosis Mibelli consists of a single plaque or a small number of plaques of variable size, usually located unilaterally on limbs. . DSP is a variant of PM characterized by small erythematous or pigmented keratotic papules with central atrophy, located on the trunk, genitals, palms, and soles

References

↑ Freedberg, et al. (2003). Fitzpatrick's Dermatology in General Medicine. (6th ed.). McGraw-Hill. ISBN 0-07-138076-0.
↑ James, William; Berger, Timothy; Elston, Dirk (2005). Andrews' Diseases of the Skin: Clinical Dermatology. (10th ed.). Saunders. ISBN 0-7216-2921-0.

Template:WikiDoc Sources

[Fitz2-1] Freedberg, et al. (2003). Fitzpatrick's Dermatology in General Medicine. (6th ed.). McGraw-Hill. ISBN 0-07-138076-0.

[Andrews-2] James, William; Berger, Timothy; Elston, Dirk (2005). Andrews' Diseases of the Skin: Clinical Dermatology. (10th ed.). Saunders. ISBN 0-7216-2921-0.

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