Zieve's syndrome

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Zieve's syndrome is an acute metabolic condition that can occur during withdrawal from prolonged alcohol abuse. It is defined by hemolytic anemia, hyperlipoproteinaemia (excessive blood lipoprotein), jaundice, and abdominal pain. The underlying cause is liver delipidization. This is distinct from alcoholic hepatitis, which however may be subsequent or copresent.

Reference

• Zieve L. Jaundice, hyperlipemia and hemolytic anemia: A heretofore unrecognized syndrome associated with alcoholic fatty liver and cirrhosis. Ann Intern Med. 1958;48:471-96. PMID 13521581.

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