Hyperlipoproteinemia classification

Lipoprotein Disorders Main Page
Hyperlipoproteinemia Microchapters
Hypercholesterolemia Patient Information
Hypertriglyceridemia Patient Information
Overview
Classification Familial hyperchylomicronemia Familial hypercholesterolemia Familial combined hyperlipidemia Dysbetalipoproteinemia Primary hypertriglyceridemia Mixed hyperlipoproteinemia
Differential Diagnosis
Screening
ACC/AHA Guideline Recommendations
Summary
Treatment
Major recommendations for statin therapy
Therapeutic response to statin therapy
Blood cholesterol LDL and non-HDL treatment goals
Treatment in heart failure and hemodialysis
Primary prevention
Secondary prevention
Intensity of statin therapy in primary and secondary prevention
Safety Recommendations
Guideline on Lifestyle Management

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Hyperlipoproteinemia can be classified into primary and secondary hyperlipoproteinemia depending on the etiology. Primary lipoprotein disorders, caused by genetic mutations, can affect mainly the LDL particle, HDL, or more than one lipoprotein at the same time. In addition, secondary lipoproteinemia include medical conditions that lead to low lipoprotein levels.

Classification

Etiology

Shown below is an algorithm depicting the classification of hyperlipoproteinemia into primary and secondary.

Hyperlipoproteinemia

Primary (Genetic)

Secondary

Laboratory Results

Hyperlipoproteinemia can be classified according to which major lipoprotein or major lipid affected as detected in blood laboratory tests:

High Lipoprotein

• High chilomicron remnant
• High chylomicron
• High HDL
• High IDL
• High LDL
• High VLDL

High Lipid

• High total cholesterol
• High triglyceride