CARE Trial
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Objective
To assess if pravastatin would reduce the sum of fatal coronary artery disease (CAD) and nonfatal myocardial infarction (MI) in patients who had a previous MI and a total cholesterol value < 240 mg/dl.
Methods
Cholesterol and Recurrent Events trial was a double blinded, randomized study wherein 4159 patients with a history of a myocardial infarction in the previous two years who had a total cholesterol value < 240 mg/dl were enrolled and treated with either 40 mg pravastatin or a placebo.
Results
The following results were obtained after a median follow-up time of 5 years:
- Reduced combined end point of coronary death and nonfatal MI (10.2 versus 13.2 percent)
- Reduced need for revascularization with CABG or PTCA (14.1 versus 18.8 percent)
- Reduced frequency of stroke (2.6 versus 3.8 percent) and of stroke plus transient ischemic attacks (4.4 versus 6.0 percent)[1][2]
References
- ↑ Sacks FM, Pfeffer MA, Moye LA; et al. (1996). "The effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels. Cholesterol and Recurrent Events Trial investigators". The New England Journal of Medicine. 335 (14): 1001–9. doi:10.1056/NEJM199610033351401. PMID 8801446. Unknown parameter
|month=ignored (help) - ↑ Pfeffer MA, Sacks FM, Moyé LA; et al. (1995). "Cholesterol and Recurrent Events: a secondary prevention trial for normolipidemic patients. CARE Investigators". The American Journal of Cardiology. 76 (9): 98C–106C. PMID 7572695. Unknown parameter
|month=ignored (help)