High density lipoprotein pathophysiology

	High Density Lipoprotein Microchapters
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Rim Halaby, M.D. [2]

Overview

Pathophysiology

Insulin Resistance

Shown below is an image depicting the self perpetuating bidirectional relationship between insulin resistance and low HDL.

Adapted from Nature Reviews Endocrinology.^[1]

↑ Drew BG, Rye KA, Duffy SJ, Barter P, Kingwell BA (2012). "The emerging role of HDL in glucose metabolism". Nat Rev Endocrinol. 8 (4): 237–45. doi:10.1038/nrendo.2011.235. PMID 22271188.

Template:WikiDoc Sources

[pmid22271188-1] Drew BG, Rye KA, Duffy SJ, Barter P, Kingwell BA (2012). "The emerging role of HDL in glucose metabolism". Nat Rev Endocrinol. 8 (4): 237–45. doi:10.1038/nrendo.2011.235. PMID 22271188.

[1]

v t e Lipopedia
Basic Science	Cholesterol • Triglyceride Lipoprotein metabolism and transport Lipoprotein: Chylomicron • Chylomicron remnant • HDL • IDL • LDL • Lipoprotein(a) • VLDL • Lipoprotein-X Apolipoprotein: APOA (1, 2, 4, 5) • APOB ( Apolipoprotein B-48, Apolipoprotein B-100) • APOC (1, 2, 3, 4) • APOD • APOE • APOH • APOJ • APOL • APOM • Apo(a) Lipoprotein receptor: LDL receptor • Soluble low density lipoprotein receptor-related protein (sLRP) • Apolipoprotein E Receptor 2 • Scavenger receptor • Scavenger receptor A • Scavenger receptor B • VLDL receptor Lipoprotein enzymes: Lipoprotein lipase • Lipoprotein-associated phospholipase A2 (Lp-PLA2) • Cholesterylester transfer protein ( Acetyl-CoA C-acyltransferase, Lecithin-cholesterol acyltransferase) • Microsomal triglyceride transfer protein • ABCA1 Genes: Low density lipoprotein receptor gene family • Microsomal triglyceride transfer protein • ABCA1
Lipoprotein Disorders	Lipoprotein disorders Primary lipoprotein disorders: Familial hyperchylomicronemia (Type I) • Familial hypercholesterolemia (Type IIA) • Familial combined hyperlipidemia (Type IIB) • Dysbetalipoproteinemia (Type III) • Primary hypertriglyceridemia (Type IV) • Mixed hyperlipoproteinemia (Type V) Secondary lipoprotein disorders
Abnormal Laboratory Lipid Profile	Low chylomicron • Low chylomicron remnant • Low HDL • Low IDL • Low LDL • Low lipoprotein(a) • Low VLDL High chylomicron • High chylomicron remnant • High HDL • High IDL • High LDL • High Lipoprotein(a) • High VLDL

High density lipoprotein pathophysiology

Overview

Pathophysiology

Insulin Resistance

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