IgA nephropathy historical perspective
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Historical Perspective
IgA nephropathy was first described by Jean Berger, a pathologist, and Nicole Hinglais, an electron microscopist, in 1968 in France.[1][2][3] In the original one-page article titled “Les depots intercapillaires d'IgA-IgG” in the “journal d’Urologie-Nephrologie”, the authors describe the renal disease under light microscopy showing focal and segmental mesangial proliferation with expansion of the matrix. Under electron microscopy, they noted the predominance of IgA deposits in the renal mesangium that were associated with the presence of less significant presence of IgG and C3. The association of IgA nephropathy with Henoch-Schonlein purpura was made very shortly by Berger following the first description of IgA nephropathy in 1969.[1]
References
- ↑ 1.0 1.1 Berger J (1969). "IgA glomerular deposits in renal disease". Transplant Proc. 1 (4): 939–44. PMID 4107073.
- ↑ Berger J, Hinglais N (1968). "[Intercapillary deposits of IgA-IgG]". J Urol Nephrol (Paris). 74 (9): 694–5. PMID 4180586.
- ↑ Feehally J, Cameron JS (2011). "IgA nephropathy: progress before and since Berger". Am J Kidney Dis. 58 (2): 310–9. doi:10.1053/j.ajkd.2011.03.024. PMID 21705126.