Renal cell carcinoma historical perspective
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Renal cell carcinoma was first described by Koenig in 1826, when he published his pathological classification of renal tumors. At the time, he classified renal tumors according to their macroscopic forms: scirrhous, steatomatous, fungoid, and medullary.(1) In 1883, Grawitz, a German pathologist, noted that alveolar (clear cell) renal tumors differed from their papillary counterparts. He stated that clear cell renal tumors, previously characterized by their lipomatous components, are neoplastic tumors called hypernephromas that originate from transformed adrenal cortical tissue into renal cortical tissue.[1] On the other hand, Sudeck and Robin disagreeably hypothesized that both alveolar and papillary tumors originate from the same renal tubular origin.(3) It was not until 1960 when Oberling and colleagues[2] proved finally that clear cell renal carcinomas originate from renal tubular cells in their publication "Ultrastructure of the clear cells in renal carcinomas and its importance for the demonstration of their renal origin".
It was not until 1909 that the term hypernephroma was coined
References
- ↑ {{cite journal| author=Grawitz VP|title=Die sogenannten lipome de niere | journal=Pathol Anat | year= 1883 | volume= 93 | issue= |pages=39
- ↑ OBERLING C, RIVIERE M, HAGUENAU F (1960). "Ultrastructure of the clear cells in renal carcinomas and its importance for the demonstration of their renal origin". Nature. 186: 402–3. PMID 14428164.